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I0911

Sigma-Aldrich

IRR (945-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinónimos:

INSRR

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About This Item

UNSPSC Code:
12352204
NACRES:
NA.32

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

94-128 nmol/min·mg

mol wt

~65 kDa

UniProt accession no.

P14616

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... INSRR(3645)

General description

IRR (insulin receptor-related receptor) belongs to the insulin receptor (IR) family. It is expressed in neuronal tissues, kidney, pancreas and stomach.

Biochem/physiol Actions

IRR or insulin receptor-related receptor is a tyrosine protein kinase. IRR is an extracellular pH sensor. The IRR mRNA is present in neuroblastomas and may be associated with tumor genesis.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Igor E Deyev et al.
The Journal of biological chemistry, 288(47), 33884-33893 (2013-10-15)
IRR is a member of the insulin receptor (IR) family that does not have any known agonist of a peptide nature but can be activated by mildly alkaline medium and was thus proposed to function as an extracellular pH sensor.
B Zhang et al.
The Journal of biological chemistry, 267(26), 18320-18328 (1992-09-15)
In 1989, Shier and Watt identified a gene which was predicted to encode a new member of the insulin receptor (IR) family, and they called it the insulin receptor-related receptor (IRR) (Shier, P., and Watt, V. M. (1989) J. Biol.
M W Elmlinger et al.
Regulatory peptides, 84(1-3), 37-42 (1999-10-27)
The insulin receptor-related receptor (IRR) is a member of the insulin receptor family. So far no ligand has yet been discovered for this receptor type (orphan receptor). IRR, insulin receptor (IR), and insulin-like growth factor-I receptor (IGF-I-R) are all tyrosine

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