H0915

Sulfato de hidroxicloroquina

≥98% (HPLC), powder, anti-inflammatory

• Sinónimos: Sulfato de 7-cloro-4-[4-(N-etil-N-b-hidroxietilamino)-1-metilbutilamino]quinolina
• Fórmula empírica (notación de Hill): C₁₈H₂₆ClN₃O · H₂SO₄
• Número de CAS: 747-36-4
• Peso molecular: 433.95
• EC Number: 212-019-3
• MDL number: MFCD00078203
• UNSPSC Code: 12352200
• PubChem Substance ID: 329815141
• NACRES: NA.77

Propiedades

• product name: Sulfato de hidroxicloroquina, ≥98% (HPLC), powder
• assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to off-white
• solubility: H₂O: >20 mg/mL
• SMILES string: OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
• InChI: 1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
• InChI key: JCBIVZZPXRZKTI-UHFFFAOYSA-N
• Gene Information: human ... TLR7(51284) , TLR9(54106)

Descripción

Application

Hydroxychloroquine sulfate has been used:

• as an inhibitor of autophagy to treat cells for apoptosis assay to study the role of pirarubicin induced autophagy in bladder cancer cell line
• to evaluate the antiviral mechanism of hydroxychloroquine against DENV-2 (dengue virus-2) infection by immunofluorescence assay
• to inhibit lysosome fusion with the autophagosome

Biochem/physiol Actions

El sulfato de hidroxicloroquina es un antiinflamatorio (vía TNF), un antirreumático modificador de la enfermedad (DMARD) y un inhibidor de la hemo polimerasa. Se utiliza para tratar el paludismo.

Hydroxychloroquine is also used for treating rheumatoid arthritis and systemic lupus erythematosus.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319
• pcodes: P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves