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Merck

GW22679

Sigma-Aldrich

Anti-Progesterone Receptor antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-22679

technique(s)

western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PGR(5241)

General description

PGR (progesterone receptor) is a member of nuclear receptor superfamily, the members of which act as transcription factors. It exists in two isoforms PRA and PRB. PRB contains an additional sequence of 164 amino acids at its N-terminal, which is absent in PRA. They have two activation function domains- AF-1 and AF-2. AF-1 is responsible for the activation of PGR-independent of ligand, whereas AF-2 mediates PGR-activation in a ligand-dependent manner. PRB also contains AF-3, present in the N-terminal. It has a variable N-terminal region, a DNA-binding domain, which is highly conserved in nature, and a ligand-binding domain at its C-terminal region. The DNA-binding domain and the ligand-binding domain are connected via a hinge domain. This gene is localized to human chromosome 11.q13.

Immunogen

Immunogen Sequence: GI # 31981492, sequence 61-350
Recombinant progesterone receptor

Application

Anti-Progesterone Receptor antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

The progesterone receptor (PR) protein is an inherent testicular protein and not a secretion of accessory reproductive organs. PR is expressed in human testis and in various reproductive tissues. It can serve as a marker to define the fertilizing potential of the spermatozoa. PR acts as an important marker for hormone dependence and disease prognosis. It is expressed in prostate stromal cells, where it regulates cell motility. Down-regulation of this protein in prostate stromal cancer cells, might lead to increased stromal derived factor-1 (SDF-1) and interlukin-6 (IL-6) levels, which in turn might promote tumor progression. In breast cancer, PGR and activator protein 1 (AP-1) nuclear interaction serves as a marker of favorable prognosis and overall patient survival, in cases treated with tamoxifen.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Visite la Librería de documentos

Sushama Gadkar-Sable et al.
Frontiers in bioscience : a journal and virtual library, 10, 2118-2130 (2005-06-23)
The unequivocal role of progesterone in a variety of events like ovulation, mammary gland development, establishment and maintenance of pregnancy etc are well established. Also the data are accumulating on its role in male reproductive events. In vertebrates and humans
María C Díaz Flaqué et al.
Breast cancer research : BCR, 15(6), R118-R118 (2013-12-19)
The role of the progesterone receptor (PR) in breast cancer remains a major clinical challenge. Although PR induces mammary tumor growth, its presence in breast tumors is a marker of good prognosis. We investigated coordinated PR rapid and nonclassical transcriptional
M L Law et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(9), 2877-2881 (1987-05-01)
Progesterone is involved in the development and progression of breast cancers, and progesterone receptors (PR) are important markers of hormone dependence and disease prognosis. We have used a human PR cDNA probe, genomic DNA blotting of a series of Chinese
Yue Yu et al.
PloS one, 9(3), e92714-e92714 (2014-03-26)
Reciprocal interactions between epithelium and stroma play vital roles for prostate cancer development and progression. Enhanced secretions of cytokines and growth factors by cancer associated fibroblasts in prostate tumors create a favorable microenvironment for cancer cells to grow and metastasize.
Hwa Hwa Chung et al.
The Journal of biological chemistry, 289(9), 5704-5722 (2014-01-15)
Progesterone receptor (PR) exists in two isoforms, PRA and PRB, and both contain activation functions AF-1 and AF-2. It is believed that AF-1 is primarily responsible for the ligand-independent activity, whereas AF-2 mediates ligand-dependent PR activation. Although more than a

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