GW22678

Anti-ERB antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: chicken
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: mouse, rat, human
• manufacturer/tradename: Genway 15-288-22678
• technique(s): western blot: suitable
• NCBI accession no.: NP_001428.1
• UniProt accession no.: Q59F41
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... ESR2(2100)

Descripción

General description

Estrogen receptor β (ERB) belongs to a family of nuclear receptors, which function as regulators of homeostasis. There are two types of ER- ERα and ERβ, and ERs form the class I of nuclear receptors. They are normally sequestered as multi-protein complex in the cytoplasm, until activated by their ligands. It contains a DNA-binding domain, a hinge domain, and AF1 domain, and a ligand-binding domain. It has a high level of expression in normal breast cells.

Immunogen

Immunogen Sequence: GI # 10835013, sequence 1-150

Recombinant estrogen receptor β isoform 1

Application

Anti-ERB antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Estrogen receptor β (ERB) functions as a transcription factor, and modulates the transcription of target genes, which are components of cell cycle including cyclins and proto-oncogenes. It activates growth-inhibitory genes and thus, functions in suppressing cell proliferation. It negates the activation of anti-apoptotic genes by ERα, via 17β-estradiol. It is inactivated in breast cancer (BC), which marks an important stage in the progression of BC, in an estrogen-dependent manner. The presence of this gene is BC has prognostic value for tamoxifen-treated patients, and might also have potential as a therapeutic target. Mitochondrial ERβ2 has anti-apoptotic functions, and thus predicts poor prognosis in serous ovarian cancer.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)