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Merck

GW22651

Sigma-Aldrich

Anti-Spondin-1 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, rat, mouse

manufacturer/tradename

Genway 15-288-22651

technique(s)

western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SPON1(10418)

Immunogen

Immunogen Sequence: GI # 24307905, sequence 549-807
Recombinant spondin 1, extracellular matrix protein

Application

Anti-Spondin-1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Spondin-1 (also known as F-spondin) is a protein encoded by the SPON1 gene in humans. It is an extracellular matrix protein that mediates axon guidance during neuronal development and consists of an N-terminal domain called as reelin-N domain. F-spondin highly expressing human periodontal ligament (HPL) cells show similar phenotype of cementoblasts. It acts as a promoting factor for cementoblastic differentiation.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


Certificados de análisis (COA)

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Kemin Tan et al.
Journal of molecular biology, 381(5), 1213-1223 (2008-07-08)
The extracellular matrix protein F-spondin mediates axon guidance during neuronal development. Its N-terminal domain, termed the reelin-N domain, is conserved in F-spondins, reelins, and other extracellular matrix proteins. In this study, a recombinant human reelin-N domain has been expressed, purified
Masae Kitagawa et al.
Biochemical and biophysical research communications, 349(3), 1050-1056 (2006-09-13)
Cementum is a mineralized tissue produced by cementoblasts covering the roots of teeth that provides for the attachment of periodontal ligament to roots and surrounding alveolar bone. To study the mechanism of proliferation and differentiation of cementoblasts is important for

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