GW22280A

Anti-KLHL12 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-C3IP1, Anti-DKIR
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: chicken
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• reactividad de especies: human
• fabricante / nombre comercial: Genway 15-288-22280A
• técnicas: western blot: suitable
• Nº de acceso NCBI: NP_067646.1
• Nº de acceso UniProt: Q53G59
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... KLHL12(59349)

Descripción

Descripción general

Kelch-like protein 12 is a novel human kelch protein localized to a ring canal structure. It consists of N-terminal POZ (poxviruses and zinc fingers) and intervening region (IVR) domains. It plays an important role in the ring-like structure activity during oocyte development.

Inmunógeno

Immunogen Sequence: GI # 11056006, sequence 205-404

Recombinant kelch-like 12

Aplicación

Anti-KLHL12 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Acciones bioquímicas o fisiológicas

Kelch-like protein 12 is a protein encoded by the KLHL12 gene in humans. It is a Bric à Brac (BTB)-Kelch protein and specifically binds to the polymorphic region of the D4 receptor through its Kelch domain. KLHL12 also interacts with Cullin3 and functions as an adaptor to target the D4 receptor to an E3 ubiquitin ligase complex. Its overexpression strongly promotes ubiquitination of the D4 receptor. KLHL12 is essential for the development of the ring-like structure, which is independent of the ability to bind actin. It interacts with both immature, ER-associated and mature, plasma membrane-associated D4 receptors, β-arrestin2, and also promotes ubiquitination of both receptor subpools.

Forma física

Solution in phosphate buffered saline containing 0.02% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)