This product has not been studied in-house for in vivo applications. Please refer to published literature for relevant citations regarding its use in murine models.
G8048
GLP-1R agonist
≥98% (HPLC), powder, glucose homeostasis regulator
Sinónimos:
2-Quinoxalinamine, 6,7-dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)-, 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline (DMB), Compound 2
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5 MG
US$ 277,00
25 MG
US$ 1.110,00
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Cambiar Vistas
5 MG
US$ 277,00
25 MG
US$ 1.110,00
About This Item
Fórmula empírica (notación de Hill):
C13H15Cl2N3O2S
Número de CAS:
Peso molecular:
348.25
Número MDL:
Código UNSPSC:
12352200
NACRES:
NA.77
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Nombre del producto
GLP-1R agonist, ≥98% (HPLC)
Ensayo
≥98% (HPLC)
Formulario
powder
condiciones de almacenamiento
desiccated
color
light brown-yellow
solubilidad
DMSO: ≥10 mg/mL
temp. de almacenamiento
2-8°C
cadena SMILES
[S](=O)(=O)(C)c1nc2c(nc1NC(C)(C)C)cc(c(c2)Cl)Cl
InChI
1S/C13H15Cl2N3O2S/c1-13(2,3)18-11-12(21(4,19)20)17-10-6-8(15)7(14)5-9(10)16-11/h5-6H,1-4H3,(H,16,18)
Clave InChI
GNZCSGYHILBXLL-UHFFFAOYSA-N
Descripción general
Acciones bioquímicas o fisiológicas
GLP-1R is a small molecule GLP-1 receptor agonist.
GLP-1R is a small molecule GLP-1 receptor agonist. GLP-1 receptor signaling is a predominant mechanism for regulating glucose homeostasis. This compound represents a unique non-peptide tool for studying the role of GLP-1 in both in vivo and in vitro diabetes and obesity models.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Is it possible to resuspend the aginist in DMSO and then dilute it in PBS without causing precipitation or affecting its solubility, with the goal of injecting it into a murine ?model
1 answer-
Helpful?
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What is the mechanism of action for this compound? Additionally, is the structural information available for this compound?
What is the mechanism of action for this compound? Additionally, is the structural information available for this compound?
1 answer-
The compound known as compound 2 was discovered through functional screening, demonstrating that it enhances the binding of GLP-1 to the receptor rather than competing with it. It functions as an ago-allosteric modulator, acting as both an agonist and an allosteric modulator. This compound is specific to the GLP-1 receptor and induces insulin release from wild-type mouse islets, as detailed in a specific article. For information on the structure of compound 2, please refer to Figure 2 in the publication "Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3): 937–942." The PMID for the article is 17213325, and it can be accessed at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783418/.
Helpful?
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What is the molecular weight of GLP1 agonist 8048 in grams ?
1 answer-
The molecular weight of this product is 348.25. This value can be interpreted in units of daltons or grams per mole.
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