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F2379

Fetuin from fetal calf serum

lyophilized powder, suitable for cell culture

Sinónimos:

Fetuin from fetal calf serum

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Talla/SKUDisponibilidadPrecio
100 mg
Comprobar disponibilidad del carrito
US$ 82,10
250 mg
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US$ 107,00
1 g
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US$ 382,00
5 g
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US$ 1.360,00
25 g
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US$ 5.220,00

Acerca de este artículo

Número CAS:
9014-81-7
UNSPSC Code:
12352202
EC Number:
232-762-7
NACRES:
NA.61
MDL number:
MFCD00131055
Form:
lyophilized powder
Biological source:
bovine serum (fetal)

US$ 82,10

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biological source

bovine serum (fetal)

Quality Segment

form

lyophilized powder

technique(s)

cell culture | mammalian: suitable

impurities

≤0.3% free N-acetylneuraminic acid

solubility

H2O: 1 mg/mL, colorless to faint yellow or tan

UniProt accession no.

storage temp.

2-8°C

Gene Information

bovine ... FETUA(504615)

General description

Fetuin from fetal bovine serum is a 64 kDa plasma glycoprotein. It is produced by the liver and adipose tissue.

Application

Fetuin is a protein with the ability to bind to the insulin receptor and inhibit insulin action. Fetuin has been used in studies of type 2 diabetes mellitus (T2DM). In patients with T2DM, fetuin has been shown to be significantly lower when compared to control patients. Fetuin has also been used in studies to demonstrate its protective role in the development of arterial calcification.
Fetuin from fetal bovine serum has been used:
  • to synthesize primary and secondary calciprotein particles (CPP)
  • to study the binding of Xerocomus chrysenteron lectin (XCL) to the T antigen expressed by membrane proteins
  • as a supplement in Ham′s F10 media for myoblast culture.

Biochem/physiol Actions

Fetuin, an inhibitor of insulin receptor tyrosine kinase, modulates bone remodeling and calcium metabolism. It is involved in keratinocytes migration and breast tumor cell proliferative signaling. Fetuin also regulates vascular calcification, insulin resistance and protease activity It acts as a biomarker for neurodegenerative diseases. Fetuin has anti-inflammatory property.

Preparation Note

Prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).

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Este artículo
F3004F3385341506
Fetuin from fetal calf serum lyophilized powder, suitable for cell culture

Sigma-Aldrich

F2379

Fetuin from fetal calf serum

Fetuin from fetal calf serum lyophilized powder

Sigma-Aldrich

F3004

Fetuin from fetal calf serum

Fetuin from fetal calf serum lyophilized powder, BioReagent, suitable for cell culture

Sigma-Aldrich

F3385

Fetuin from fetal calf serum

Fetuin, Fetal Bovine Serum

Sigma-Aldrich

341506

Fetuin, Fetal Bovine Serum

description

lyophilized powder, suitable for cell culture

description

lyophilized powder

description

lyophilized powder, BioReagent, suitable for cell culture

description

-

biological source

bovine serum (fetal)

biological source

bovine serum (fetal)

biological source

-

biological source

bovine serum

technique(s)

cell culture | mammalian: suitable

technique(s)

HPLC: suitable, MALDI-MS: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized solid

solubility

H2O: 1 mg/mL, colorless to faint yellow or tan

solubility

-

solubility

H2O: 1 mg/mL

solubility

water: 50 mg/mL

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

impurities

≤0.3% free N-acetylneuraminic acid

impurities

~0.2% free N-acetylneuraminic acid

impurities

≤0.3% free N-acetylneuraminic acid

impurities

-

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Clase de almacenamiento

11 - Combustible Solids

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)

Not applicable

EPI (equipos de protección individual)

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

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Questions

1–4 of 4 Questions  

  1. Which assay is used to measure N-acetylneuraminic acid content?

    1 answer

    1. The specific method use to determine N-acetylneuaminic acid (NANA) is considered proprietary. However, the assay is a modification of a Neuraminidase enzymatic assay. A prepared fetuin solution is hydrolyzed chemically to determine the "total NANA".

      Two concentrations of a NANA standard are utilized, 0.150 mg/ml for total NANA and 0.06 mg/ml for free NANA, and test is monitored at 550 nm.

      The free NANA, monitored at 340 nm, is done to confirm results.

      Please see the link below to review additional information available in the product datasheet:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/127/380/f2379pis.pdf

      Helpful?

  2. Is there information available on the content/concentration of bovine IgG and BSA in the fetuin products F2379 and F3385 (CAS 9014-81-7)?

    1 answer

    1. Testing for bovine IgG and BSA is not conducted in the final product. A purity agarose gel is performed on F2379, but quantification, testing, or reporting for IgG and BSA is not done. Additionally, the marker size used for QC testing is uncertain, and both IgG and BSA are larger than fetuin.

      Helpful?

  3. How pure is this fetuin? There's a protein content % but could there be other proteins from serum present when using ammonium sulfate fractionation?

    1 answer

    1. Product F2379 can not be considered pure Fetuin. Neither the purity, nor the identity of potential contaminating proteins, is determined.

      Helpful?

  4. Is there a good antibody to recognize this bovine fetuin B by western blot?

    1 answer

    1. Unfortunately, the Fetuin antibodies currently available are not tested against bovine. While fetuin is fairly conserved from bovine to human, reactivity cannot be predicted. See the links below for fetuin antibodies against human that have been testing for use in western blot.

      ABN1469
      https://www.sigmaaldrich.com/product/mm/abn1469

      SAB5701234
      https://www.sigmaaldrich.com/product/sigma/sab5701234

      Helpful?

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