E9750

Estrone

≥99% (HPLC), powder, estrogen receptor agonist

• Sinónimos: 1,3,5(10)-Estratrien-3-ol-17-one, 3-Hydroxy-1,3,5(10)-estratrien-17-one, Folliculin
• Fórmula empírica (notación de Hill): C₁₈H₂₂O₂
• Número de CAS: 53-16-7
• Peso molecular: 270.37
• Beilstein: 1915077
• Número CE: 200-164-5
• Número MDL: MFCD00003620
• Código UNSPSC: 51111800
• ID de la sustancia en PubChem: 24278427
• NACRES: NA.77

Propiedades

• Nombre del producto: Estrone, ≥99%
• origen biológico: synthetic (organic)
• esterilidad: non-sterile
• Ensayo: ≥99%
• Formulario: powder
• mp: 258-260 °C (lit.)
• solubilidad: dioxane: 50 mg/mL, clear, colorless to very faintly yellow
• Condiciones de envío: ambient
• temp. de almacenamiento: room temp
• cadena SMILES: C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O
• InChI: 1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1
• Clave InChI: DNXHEGUUPJUMQT-CBZIJGRNSA-N
• Información sobre el gen: human ... ESR1(2099) , ESR2(2100) , ESRRA(2101) , ESRRB(2103) , HSD17B1(3292) , SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Esr1(24890)

Descripción

Descripción general

Estrone is a weak form of estrogen and exists as estrone sulphate.[1] Estrone is a luteolytic estrogen produced by the corpus luteum.[2] In the follicle, estrone is synthesized from androstenedione by the action of cytochrome P450 aromatase.[3]

Aplicación

Estrone has been used:

• as medium supplement for hormone based degranulation studies of natural killer cells[4]
• as an endocrine disrupting compound for screening bacterial biosensor in toxic water.[5]
• as medium component for monitoring fatty acid synthase (FASN) activity in breast adenocarcinoma cell lines[6]

Acciones bioquímicas o fisiológicas

Estrone is an agonist for the estrogen receptor.[7] The estradiol to estrone interconversion is favourable in menopause.[7] Oral hormone replacement therapy (HRT) of estradiol-17β increases circulating levels of estrone.[8]

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Danger
• Frases de peligro: H351,H360FD,H362
• Consejos de prudencia: P202 - P260 - P263 - P264 - P280 - P308 + P313
• Clasificaciones de peligro: Carc. 2 - Lact. - Repr. 1A
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges