E2764
Anti-Endothelin Receptor B antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Sinónimos:
Anti-ET-B, Anti-ET-Specific Endothelin Receptor
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About This Item
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Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
lyophilized powder
reactividad de especies
rat
técnicas
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100
western blot (chemiluminescent): 1:200
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
rat ... Ednrb(50672)
Descripción general
Endothelin Receptor B (EDNRB) is a G-protein coupled receptor and that consists of seven transmembrane domains. EDNRB gene is located on the human chromosome at 13q22.3.
Inmunógeno
synthetic peptide corresponding to amino acids 298-313 of rat endothelin receptor type B. The epitope is identical in all known vertebrate ET-B receptors
Aplicación
Anti-Endothelin Receptor B antibody produced in rabbit has been used in immunohistochemistry (1:100).
Acciones bioquímicas o fisiológicas
EDNRB Endothelin receptor type B (ETB) plays a pivotal role in oesophageal cancer and may act as a therapeutic target for this intractable malignancy. It has a novel role in oligodendroglioma proliferation and acts as a potential therapeutic alternative for oligodendrogliomas. Lower expression of ETB receptor responsiveness is associated with polycystic ovary syndrome (PCOS) and may reflect lower endothelial-mediated vasodilatation independent of generally lower vascular reactivity.
Mutations in the EDNRB gene are associated with Hirschsprung disease.
Forma física
Lyophilized at 0.8 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Órganos de actuación
Respiratory system
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Chun-Yun Wu et al.
Glia, 54(6), 513-525 (2006-08-10)
Amoeboid microglial cells (AMC) which transiently exist in the corpus callosum in the postnatal rat brain expressed endothelins (ETs), specifically endothelin-1 (ET-1) and ET3 as revealed by real time RT-PCR. ET immunoreactive AMC occurred in large numbers at birth, but
J Amiel et al.
Human molecular genetics, 5(3), 355-357 (1996-03-01)
Hirschsprung disease (HSCR, aganglionic megacolon) is a frequent congenital malformation regarded as a multigenic neurocristopathy. Two susceptibility genes have been recently identified in HSCR, namely the RET proto-oncogene and the endothelin B receptor (EDNRB) gene. Hitherto however, homozygosity for EDNRB
M K Shin et al.
Nature, 402(6761), 496-501 (1999-12-11)
Endothelin receptor B (EDNRB) is a G-protein-coupled receptor with seven transmembrane domains which is required for the development of melanocytes and enteric neurons. Mice that are homozygous for a null mutation in the Ednrb gene are almost completely white and
T Sakurai et al.
Nature, 348(6303), 732-735 (1990-12-20)
Endothelin-1 was initially identified as a 21-residue potent vasoconstrictor peptide produced by vascular endothelial cells, but was subsequently found to have many effects on both vascular and non-vascular tissues. The discovery of three isopeptides of the endothelin family, ET-1, ET-2
Victor M Salinas-Torres et al.
Pediatric surgery international, 34(9), 931-943 (2018-08-11)
Gastroschisis has been assumed to have a low rate of syndromic and primary malformations. We aimed to systematically review and explore the frequency and type of malformations/chromosomal syndromes and to identify significant biological/genetic roles in gastroschisis. Population-based, gastroschisis-associated anomalies/chromosomal defects
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