E125

β-Estradiol

• Sinónimos: 1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin
• Fórmula empírica (notación de Hill): C₁₈H₂₄O₂
• Número CAS: 50-28-2
• Peso molecular: 272.38
• EC Number: 200-023-8
• UNSPSC Code: 12352200
• PubChem Substance ID: 329798995
• Beilstein/REAXYS Number: 1914275
• MDL number: MFCD00003693

Propiedades

• mp: 176-180 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C
• InChI: 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
• InChI key: VOXZDWNPVJITMN-ZBRFXRBCSA-N
• Gene Information: human ... ESR1(2099)

Descripción

Biochem/physiol Actions

The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

The major estrogen secreted by the premenopausal ovary.

Información de seguridad

• Clase de almacenamiento: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: 188.6 °F
• flash_point_c: 87 °C
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges