This product is a multi-component item comprised of dexamethasone and (2-Hydroxypropyl)-?-cyclodextrin. The molecular weight of Dexamethasone is 392.5 g/mol. The molecular weight of the (2-Hydroxypropyl)-?-cyclodextrin is variable, but has an average molecular weight of 1,396 g/mol. There is an excess of cyclodextrin in the mixture to greatly enhance the solubility of the dexamethasone. The product is sold on the basis of the Dexamethasone content. The final product will have 55 - 75 mg of Dexamethasone per gram solid. For example, a 100mg package reporting a 75mg/gram Dexamethasone concentration would be a package of 1.81 grams. This value is reported in the Certiicate of Analysis. Please see the link below to review a sample of a specific Certificate:
https://www.sigmaaldrich.com/US/en/product/sigma/d2915#product-information
D2915
Dexamethasone-Water Soluble
suitable for cell culture, BioReagent
Sinónimos:
Dexamethasone – Cyclodextrin complex
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About This Item
Productos recomendados
biological source
synthetic (organic)
Quality Level
product line
BioReagent
form
solid
technique(s)
cell culture | mammalian: suitable
solubility
H2O: 25 mg/mL, clear to slightly hazy
shipped in
ambient
storage temp.
room temp
SMILES string
C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)C3[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO.OC[C@H]5O[C@@H]6O[C@H]7[C@H](O)[C@@H](O)[C@H](O[C@@H]7CO)O[C@H]8[C@H](O)[C@@H](O)[C@H](O[C@@H]8CO)O[C@H]9[C@H](O)[C@@H](O)[C@H](O[C@@H]9CO)O[C@H]%10[C@H](O)[C@@H](O)[C@H](O[C@@H]%10CO)O[C@H]%11[C@H](O)[C@@H](O)[C@H](O[C@@H]%11CO)O[C@H]%12[C@H](O)[C@@H](O)[C@H](O[C@@H]%12CO)O[C@H]5[C@H](O)[C@H]6O
InChI
1S/C42H70O35.C22H30O4/c43-1-8-29-15(50)22(57)36(64-8)72-30-9(2-44)66-38(24(59)17(30)52)74-32-11(4-46)68-40(26(61)19(32)54)76-34-13(6-48)70-42(28(63)21(34)56)77-35-14(7-49)69-41(27(62)20(35)55)75-33-12(5-47)67-39(25(60)18(33)53)73-31-10(3-45)65-37(71-29)23(58)16(31)51;1-12-8-16-15-5-4-13-9-14(24)6-7-21(13,2)20(15)17(25)10-22(16,3)19(12)18(26)11-23/h8-63H,1-7H2;6-7,9,12,15-17,19-20,23,25H,4-5,8,10-11H2,1-3H3/t8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-;12-,15+,16?,17+,19-,20-,21+,22+/m11/s1
InChI key
XEJNDGTUKUMQNG-ARJMFYCQSA-N
Application
- Dulbecco′s modified Eagle medium based osteogenic and adipogenic medium for human mesenchymal stem cell culture[1]
- erythroid expansion media for the growth of liver, bone marrow and spleen tissues[2]
- medium 199 (M199) for hepatocyte culture[3]
Biochem/physiol Actions
Packaging
Other Notes
Related product
signalword
Danger
hcodes
Hazard Classifications
Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Certificados de análisis (COA)
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Los clientes también vieron
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What is the molecular mass of Dexamethasone-Water Soluble (D2915)?
1 answer-
Helpful?
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What is the recommended method for storing prepared solutions of D2915 dexamethasone water-soluble?
1 answer-
The recommended method for storing prepared solutions of D2915 dexamethasone water-soluble is to store the solutions in working aliquots at -20°C.
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How should stock solutions for item D2915-100MG be stored?
1 answer-
Stock solutions can be stored for up to 2 months at -20°C.
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Is additional solubility data available for product D2915, Dexamethasone-Water Soluble?
1 answer-
The solubility of product D2915, Dexamethasone-Water Soluble, has been tested only in water, with a solubility (turbidity) of clear to slightly hazy at 25 mg/mL in water. Additionally, It is also soluble in ethanol (25 mg/mL), DMSO (25 mg/mL), and DMF (25 mg/mL).
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Is the 100mg labeled on the bottle of D2915 Dexamethasone for the total powder or the total dexamethasone?
1 answer-
Each vial contains 100 mg of dexamethasone. The mg of dexamethasone per gram is provided on the label, typically around 65 mg/g.
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Once this product has been reconstituted in water, how long can it be stored, and at what temperature?
1 answer-
Stock solutions may be stored in working aliquots at -20ºC. Please see the link below for additional information on the Water Soluble Complexes, including Dexamethasone, Water Soluble:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/218/859/e8014inf.pdfHelpful?
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How long is Product D2915, Dexamethasone-Water Soluble, stable in solution?
1 answer-
Dexamethasone solutions are stable for 6 months when aliquoted stored at -20 °C in a non-defrosting freezer and protected from light. However, insufficient information is available to assess the shelf-life of solutions stored at 4°C.
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Are Products D4902 and D2915, sterile?
1 answer-
No. This product is not sterile, but cell culture testing did not find the product to be toxic to cells.
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What cell lines has Product D4902, Dexamethasone, been tested on?
1 answer-
The cell lines on which this product is tested can vary from lot to lot. Some typically used cell lines are 3T3 fibroblasts, BHK, L929 and CHO.
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Do you have references for the use of Product D2915, Dexamethason - Water Soluble?
1 answer-
Here is one reference that describes using Product No. D2915: Chang, C.-J., et al., Coactivator TIF1? Interacts with Transcription Factor C/EBP? and Glucocorticoid Receptor To Induce ?1-Acid Glycoprotein Gene Expression. Mol. Cell. Biol., 18(10), 5880-5887 (1998).
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