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D144

DALDA

Name: DALDA
Brand: SIGMA

>96%, solid

Sinónimos:

[D-Arg², Lys⁴]-Dermorphin-(1-4)-amide

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About This Item

Fórmula empírica (notación de Hill):

C₃₀H₄₄N₈O₆

Número de CAS:

118476-85-0

Peso molecular:

612.72

MDL number:

MFCD00144042

UNSPSC Code:

12352200

PubChem Substance ID:

24893439

assay

>96%

form

solid

color

white

storage temp.

−20°C

SMILES string

NCCCCC(NC(=O)C(Cc1ccccc1)NC(=O)C(CCCNC(N)=N)NC(=O)C(N)Cc2ccc(O)cc2)C(N)=O

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Amino Acid Sequence

Tyr-D-Arg-Phe-Lys-NH₂

Biochem/physiol Actions

Highly selective μ opioid receptor agonist.

Storage Class

8B - Non-combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Characterization of the binding of [3H][Dmt1]H-Dmt-D-Arg-Phe-Lys-NH2, a highly potent opioid peptide.

Claire L Neilan et al.

The Journal of pharmacology and experimental therapeutics, 306(2), 430-436 (2003-03-29)

The dermorphin-derived peptide [Dmt1]DALDA (H-Dmt-d-Arg-Phe-Lys-NH2; Dmt, 2',6'-dimethyltyrosine) labels mu-opioid receptors with high affinity and selectivity in receptor binding assays. In previous studies, [Dmt1]DALDA displayed a mechanism of action distinct from that of morphine, as evidenced by its insensitivity to antisense

Mu opioid receptor expression is increased in inflammatory bowel diseases: implications for homeostatic intestinal inflammation.

D Philippe et al.

Gut, 55(6), 815-823 (2005-11-22)

Recent studies with mu opioid receptor (MOR) deficient mice support a physiological anti-inflammatory effect of MOR at the colon interface. To better understand the potential pharmacological effect of certain opiates in inflammatory bowel diseases (IBD), we (1) evaluated the regulation

Dansylated analogues of the opioid peptide [Dmt1]DALDA: in vitro activity profiles and fluorescence parameters.

Irena Berezowska et al.

Acta biochimica Polonica, 51(1), 107-113 (2004-04-20)

Dansylated analogues of the potent and selective micro opioid peptide agonist [Dmt(1)]DALDA (H-Dmt-D-Arg-Phe-Lys-NH(2); Dmt = 2',6'-dimethyltyrosine) were prepared either by substitution of N(beta)-dansyl-alpha,beta-diaminopropionic acid or N(epsilon)-dansyllysine for Lys(4), or by attachment of a dansyl group to the C-terminal carboxamide function

Synthesis and pharmacological evaluation of highly potent [Dmt1]DALDA analogs.

P Anantha Reddy et al.

Advances in experimental medicine and biology, 611, 473-474 (2009-04-30)

Type and location of fluorescent probes incorporated into the potent mu-opioid peptide [Dmt]DALDA affect potency, receptor selectivity and intrinsic efficacy.

P W Schiller et al.

The journal of peptide research : official journal of the American Peptide Society, 65(6), 556-563 (2005-05-12)

The dermorphin-derived tetrapeptide H-Dmt-d-Arg-Phe-Lys-NH(2) (Dmt = 2',6'-dimethyltyrosine) ([Dmt(1)]DALDA) is a highly potent and selective mu-opioid agonist capable of crossing the blood-brain barrier and producing a potent, centrally mediated analgesic effect when given systemically. For the purpose of biodistribution studies by

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