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D103

Sigma-Aldrich

(±)-2,3-Dichloro-α-methylbenzylamine hydrochloride

solid

Sinónimos:

DCMB, LY-78335

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About This Item

Fórmula empírica (notación de Hill):
C8H9Cl2N · HCl
Número de CAS:
39226-94-3
Peso molecular:
226.53
MDL number:
MFCD00055225
UNSPSC Code:
12352202
PubChem Substance ID:
24278157

form

solid

color

white

solubility

H2O: soluble (Solutions may be stored for 1-2 days at 4 °C.)
ethanol: soluble (Solutions may be stored for 1-2 days at 4 °C.)

SMILES string

Cl[H].CC(N)c1cccc(Cl)c1Cl

Gene Information

human ... PNMT(5409)

Biochem/physiol Actions

PNMT inhibitor.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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S P Kalra
Neuroendocrinology, 40(2), 139-144 (1985-02-01)
Adult female rats were implanted with permanent cannulae in the third ventricle of the brain and allowed to recover regular 4-day estrous cycles. They received intrajugular cannulae on the morning of proestrus and later between 12.00-13.00 h catecholamines - norepinephrine
I N Mefford et al.
Alcoholism, clinical and experimental research, 14(1), 53-57 (1990-02-01)
The probable involvement of brain epinephrine in the expression of the acute sedative and intoxicating effects of ethanol and pentobarbital is demonstrated. Two selective inhibitors of phenylethanolamine N-methyltransferase (PNMT), LY134046 and LY78335, proved to be potent and long-lasting antagonists of
L C Terry et al.
The Journal of clinical investigation, 69(1), 104-112 (1982-01-01)
Catecholamines are postulated to regulate growth hormone (GH) secretion by their influence on the release of two hypothalamic substances, somatostatin, which inhibits GH release, and GH-releasing factor, as yet unidentified. Extensive pharmacologic studies in man and animals indicate a stimulatory
N Y Liang et al.
Research communications in chemical pathology and pharmacology, 37(3), 445-452 (1982-09-01)
Inhibitors of phenylethanolamine N-methyltransferase (PNMT) were found to reduce hypothalamic and brainstem epinephrine (Epi) content, as well as the body temperature of male Sprague-Dawley rats. In the drug-treated animals, the time course for reduction of body temperature was better correlated
B A Adler et al.
Endocrinology, 113(4), 1431-1438 (1983-10-01)
Results from previous investigations have suggested an important role for central epinephrine (EPI) systems in mediating the stimulatory effects of ovarian hormones on LH release in ovariectomized female rats. The purpose of these experiments was 1) to test whether selective
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