This product, Chymase human, is an active form with activity specifications of ≥40 units/mg protein, indicating it is a mature form. The sequence information is proprietary and not available.
C8118
Chymase human
recombinant, expressed in Pichia pastoris
Sinónimos:
Mast cell protease I
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| Talla/SKU | Disponibilidad | Precio |
|---|---|---|
50 μg | Comprobar disponibilidad del carrito | US$ 824,00 |
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Número CAS:
UNSPSC Code:
12352204
NACRES:
NA.54
Número CE:
MDL number:
Specific activity:
≥40 units/mg protein
Recombinant:
expressed in Pichia pastoris
Concentration:
125-400 μg/mL
US$ 824,00
PRECIOS SIN IMPUESTOS NACIONALES
Comprobar disponibilidad del carrito
Servicio técnico
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Permítanos ayudarlerecombinant
expressed in Pichia pastoris
Quality Segment
form
liquid
specific activity
≥40 units/mg protein
mol wt
~37 kDa by SDS-PAGE
concentration
125-400 μg/mL
UniProt accession no.
application(s)
diagnostic assay manufacturing
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... CMA1(1215)
General description
Chymase is a cathepsin G-like, S1 serine proteinase found primarily in mast cells. It has a molecular mass of ~30 kDa, however its apparent molecular mass on SDS-PAGE is around 37 kDa.
Application
Chymase has been implicated in generation of angiotensin II and cleavage of big endothelin. Studies indicate it may be involved in vascular proliferation, myocardial infarction and dermatitis.
Human chymase has been used in a study to assess the effects of Panax notoginseng flower extract on the TGF-β/Smad signal transduction pathway in heart remodeling. Human chymase has also been used in a study to investigate the blood glucose level and survival in streptozotocin-treated human chymase transgenic mice.
Biochem/physiol Actions
Physical form
Supplied as a solution in 20 mM Tris, 0.8 M NaCl and 25% glycerol, pH 7.6
Other Notes
One unit hydrolyzes one micromole of N-benzoyl-L-tyrosine ethyl ester (BTEE) per minute at pH 7.8 and 25 °C. The assay buffer used to determine the enzyme activity contains 27 mM Tris-HCl, pH 7.8, with 150 mM NaCl and 0.43 mM BTEE.
1 of 1
Este artículo | |||
|---|---|---|---|
| description recombinant, expressed in Pichia pastoris | description clone B7, 2.4 mg/mL, Chemicon® | description - | description clone B7, Chemicon®, from mouse |
| specific activity ≥40 units/mg protein | specific activity - | specific activity - | specific activity - |
| Gene Information human ... CMA1(1215) | Gene Information human ... CMA1(1215) | Gene Information human ... CMA1(1215) | Gene Information human ... CMA1(1215) |
| application(s) diagnostic assay manufacturing | application(s) - | application(s) - | application(s) - |
| form liquid | form - | form liquid | form - |
| recombinant expressed in Pichia pastoris | recombinant - | recombinant - | recombinant - |
| concentration 125-400 μg/mL | concentration 2.4 mg/mL | concentration 1.1 mg/mL | concentration - |
Clase de almacenamiento
10 - Combustible liquids
¿Qué está pasando?
WGK 1
Punto de inflamación (°F)
Not applicable
Punto de inflamación (°C)
Not applicable
EPI (equipos de protección individual)
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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CMA1 has a pro form starting at amino acid 20 and a mature form starting at amino acid 22. Can you tell me which form this is or the N-term origin?
1 answer-
Helpful?
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