C1244

CHM-1 hydrate

≥99% (HPLC), solid

• Sinónimos: 2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolone hydrate, NSC 656158
• Fórmula empírica (notación de Hill): C₁₆H₁₀FNO₃ · xH₂O
• Número de CAS: 154554-41-3
• Peso molecular: 283.25 (anhydrous basis)
• MDL number: MFCD11114577
• UNSPSC Code: 12352202
• PubChem Substance ID: 329774746
• NACRES: NA.77

Propiedades

• assay: ≥99% (HPLC)
• form: solid
• storage condition: desiccated
• solubility: DMSO: ≥5 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.Fc1ccccc1C2=CC(=O)c3cc4OCOc4cc3N2
• InChI: 1S/C16H10FNO3.H2O/c17-11-4-2-1-3-9(11)12-6-14(19)10-5-15-16(21-8-20-15)7-13(10)18-12;/h1-7H,8H2,(H,18,19);1H2
• InChI key: KIAVGSCBJYDTIM-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

CHM-1 possess antimitotic,antiangiogenic and antitumor activity. It is a potent and selective antitumor agent in human hepatocellular carcinoma. CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)