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B8299

N-Butyldeoxynojirimycin

film (dried in situ), ≥98% (TLC)

Sinónimos:

Miglustat, NB-DNJ

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Talla/SKUDisponibilidadPrecio
1 mg
Comprobar disponibilidad del carrito
US$ 568,00
5 mg
Comprobar disponibilidad del carrito
US$ 2.110,00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C10H21NO4
Número CAS:
Peso molecular:
219.28
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
MDL number:

US$ 568,00

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Nombre del producto

N-Butyldeoxynojirimycin, film (dried in situ)

assay

≥98% (TLC)

Quality Segment

form

film (dried in situ)

solubility

water: 9.80-10.20 mg/mL, clear, colorless

storage temp.

2-8°C

SMILES string

CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO

InChI

1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1

InChI key

UQRORFVVSGFNRO-UTINFBMNSA-N

Gene Information

human ... UGCG(7357)

General description

N-Butyldeoxynojirimycin is an alkylated product of imino sugar deoxynojirimycin.

Application

N-Butyldeoxynojirimycin has been used:
  • in the inhibition of glycolipid synthesis in neuroblastoma cells
  • in the inhibition the ceramide-specific glycosyltransferase in hepatocytes
  • in the inhibition of β-glucosidase (GBA2) using fluorescence- activity assay in human embryonic kidney (HEK293) cells.

Biochem/physiol Actions

α-glucosidase Inhibitor
N-Butyldeoxynojirimycin is an inhibitor of glucosyltransferase and α-glucosidases. N-Butyldeoxynojirimycin, also known as misglustat, reduces glycolipid levels by substrate reduction therapy (SRT) and is effectively used for the treatment of glycosphingolipid lysosomal storage disorder, Gaucher disease.

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Este artículo
D9305M177708012
description

film (dried in situ)

description

-

description

≥98%

description

analytical standard

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥98%

assay

≥95.0% (HPLC)

Gene Information

human ... UGCG(7357)

Gene Information

human ... GAA(2548)

Gene Information

mouse ... Gaa(14387), Glb1(12091), Treh(58866)
rat ... Man2a1(25478), Si(497756)

Gene Information

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

form

film (dried in situ)

form

powder

form

powder

form

-

solubility

water: 9.80-10.20 mg/mL, clear, colorless

solubility

water: 19.60-20.40 mg/mL, clear, colorless

solubility

methanol: 10 mg/mL, clear, colorless

solubility

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-


Clase de almacenamiento

11 - Combustible Solids

¿Qué está pasando?

WGK 3

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)

Not applicable

EPI (equipos de protección individual)

Eyeshields, Gloves, type N95 (US)



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Questions

  1. How long is B8299 stable when dissolved in water, and at what temperature can I store it when it is in solution?

    1 answer
    1. The stability of this material in solution has not been investigated. However, other sources indicate that this compound is soluble in water at >35 mg/mL as well as in DMSO up to 65 mg/mL and Ethanol up to 22 mg/mL. Stock solutions may be stable for 1 month at -20°C and possibly 6 – 12 months at -80°C. Avoid repeated freeze/thaw cycles. This information has not been validated.

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