B2050

3-Bromo-7-nitroindazole

≥98% (TLC), powder

• Fórmula empírica (notación de Hill): C₇H₄BrN₃O₂
• Número CAS: 74209-34-0
• Peso molecular: 242.03
• UNSPSC Code: 12352202
• PubChem Substance ID: 24278258
• MDL number: MFCD00159910

Propiedades

• assay: ≥98% (TLC)
• form: powder
• color: light yellow
• solubility: ethanol: 25 mg/mL, DMSO: soluble
• storage temp.: 2-8°C
• SMILES string: [O-][N+](=O)c1cccc2c(Br)n[nH]c12
• InChI: 1S/C7H4BrN3O2/c8-7-4-2-1-3-5(11(12)13)6(4)9-10-7/h1-3H,(H,9,10)
• InChI key: NFSTZPMYAZRZPC-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

A potent inhibitor of all nitric oxide synthase isoforms. Shows substantial neuroprotective effects against hypoxic damage (such as stroke) and animal models of Parkinson′s disease.

A potent inhibitor of all nitric oxide synthase isoforms. Shows substantial neuroprotective effects against hypoxic damage (such as stroke) and animal models of Parkinson′s disease. Crystallographic studies show that inhibition of eNOS is due to an induced cascade of conformation changes that ultimately dissociates the tetrahydrobiopterin cofactor from the enzyme.

Información de seguridad

• pictograms: GHS08
• signalword: Danger
• hcodes: H360
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges