A6671

Actinonin

≥98% (TLC), powder, leucine aminopeptidase inhibitor

• Sinónimos: 3-[[1-[(2-(Hydroxymethyl)-1-pyrrolidinyl)carbonyl]-2-methylpropyl]carbamoyl]octanohydroxamic acid
• Fórmula empírica (notación de Hill): C₁₉H₃₅N₃O₅
• Número de CAS: 13434-13-4
• Peso molecular: 385.50
• Beilstein: 1555250
• Número MDL: MFCD00080257
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278232
• NACRES: NA.77

Propiedades

• Nombre del producto: Actinonin,
• origen biológico: synthetic (organic)
• Ensayo: ≥98% (TLC)
• Formulario: powder
• solubilidad: ethanol: 50 mg/mL, clear, colorless
• espectro de actividad antibiótica: Gram-negative bacteria; Gram-positive bacteria
• Modo de acción: enzyme | inhibits
• temp. de almacenamiento: −20°C
• cadena SMILES: CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO
• InChI: 1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)
• Clave InChI: XJLATMLVMSFZBN-UHFFFAOYSA-N
• Información sobre el gen: human ... ANPEP(290) , DPP4(1803) , ECE1(1889) , LAP3(51056)

Descripción

Descripción general

Chemical structure: peptide

Aplicación

Actinonin has been used as a control to inhibit meprin-β activity in C57BL/6 mice.[1] It has also been used to study the high-affinity interaction of EcPDF with actinonin by 15N NMR spectroscopy and isothermal titration.[2]

Acciones bioquímicas o fisiológicas

Actinonin has inhibitory action against peptide deformylase (PDF). It is effective against Gram-positive and fastidious Gram-negative microorganisms.[3]

Actinonin is an inhibitor of leucine aminopeptidase. Actinonin has also been used to improve antibacterial activity and antiobesity therapeutics.

Características y beneficios

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)