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A5475

ALX-1393

Name: ALX-1393
Brand: SIGMA

>98% (HPLC), powder

Sinónimos:

O-[(2-Benzyloxyphenyl-3-flurophenyl)methyl]-L-serine

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About This Item

Fórmula empírica (notación de Hill):

C₂₃H₂₂NO₄F

Peso molecular:

395.42

MDL number:

MFCD04974486

UNSPSC Code:

12352200

PubChem Substance ID:

24724393

assay

>98% (HPLC)

form

powder

color

white

solubility

DMSO: soluble ~20 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

N[C@@H](COC(c1cccc(F)c1)c2ccccc2OCc3ccccc3)C(O)=O

InChI

1S/C23H22FNO4/c24-18-10-6-9-17(13-18)22(29-15-20(25)23(26)27)19-11-4-5-12-21(19)28-14-16-7-2-1-3-8-16/h1-13,20,22H,14-15,25H2,(H,26,27)/t20-,22?/m0/s1

InChI key

ADUSZEGHFWRTQS-AIBWNMTMSA-N

Application

ALX-1393 is a GlyT-2 glycine transporter inhibitor and GlyT2 may be a novel therapeutic target for the treatment of overactive bladder and/or bladder hypersensitive disorders such as bladder pain syndrome/interstitial cystitis.

Biochem/physiol Actions

GlyT-2 glycine transporter inhibitor.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Glycine Transporter Type 2 (GlyT2) Inhibitor Ameliorates Bladder Overactivity and Nociceptive Behavior in Rats

Yoshikawa, S., et al.

European Urology, doi: 10-doi: 10 (2012)

Glycine receptors influence radial migration in the embryonic mouse neocortex.

Birgit Nimmervoll et al.

Neuroreport, 22(10), 509-513 (2011-06-15)

To investigate whether glycine receptors influence radial migration in the neocortex, we analyzed the effect of glycine and the glycinergic antagonist strychnine, on the distribution of 5-bromo-2'deoxyuridine-labeled neurons in organotypic slice cultures from embryonic mice cortices. Application of glycine impeded

N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn.

Hyo-Jin Jeong et al.

British journal of pharmacology, 161(4), 925-935 (2010-09-24)

The arachidonyl-amino acid N-arachidonyl-glycine (NAGly) is an endogenous lipid, generated within the spinal cord and producing spinally mediated analgesia via non-cannabinoid mechanisms. In this study we examined the actions of NAGly on neurons within the superficial dorsal horn, a key

MS Binding Assays for Glycine Transporter 2 (GlyT2) Employing Org25543 as Reporter Ligand.

Thomas M Ackermann et al.

ChemMedChem, 16(1), 199-215 (2020-08-01)

This study describes the first binding assay for glycine transporter 2 (GlyT2) following the concept of MS Binding Assays. The selective GlyT2 inhibitor Org25543 was employed as a reporter ligand and it was quantified with a highly sensitive and rapid

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