1-Acetyl-2-phenylhydrazine (AcPhHZ) which reacts with oxyhaemoglobin to form free radicals may be used to induce haemolytic anaemia for studies of the hematopoietic system.
Acciones bioquímicas o fisiológicas
1-Acetyl-2-phenylhydrazine (AcPhHZ) is a vascular tumor initiator used in experimental animal model.
The end result of our research would be the development of a new diagnostic technique that could be used as a screening test, starting from a simple blood collection, a common procedure without any risk to the subject. Red blood
Fundamental and applied toxicology : official journal of the Society of Toxicology, 32(2), 269-277 (1996-08-01)
A previous study revealed that DQ-2511, a new gastroprokinetic drug, induced hemolytic anemia together with increased Heinz body formation, preceded by a marked decrease in erythrocyte reduced glutathione (GSH) content, after 2 weeks of dosing onward in dogs. In this
Clinica chimica acta; international journal of clinical chemistry, 198(3), 239-243 (1991-05-15)
Erythrocytes of Down syndrome patients, having increased activity of superoxide dismutase and glutathione peroxidase, showed a similar increase in intracellular proteolysis upon stimulation with 1 mmol/l phenylhydrazine than normal erythrocytes. There were no differences in the magnitude of Heinz body
The Tohoku journal of experimental medicine, 186(3), 181-191 (1999-05-29)
An increase in the number of erythroblasts can be seen to some extent in the bone marrow of rats in the early stage of experimentally induced hemolytic anemia prior to any elevation in the plasma erythropoietin (Epo) level. This observation
The Journal of toxicological sciences, 25(3), 161-165 (2000-09-15)
In this study, a new simple method to measure erythrocyte fragility with stirring of diluted blood (stirring method) was introduced and evaluated with anemic rats given beta-acetylphenylhydrazine (APHZ) or clofibrate. APHZ at a dose of 40 mg/kg caused significant decreases
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
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