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Documentos clave

487R-9

SMAD4 (MRQ-72) Rabbit Monoclonal Antibody

Sinónimos:

Mothers Against Decapentaplegic Homolog 4 Rabbit Monoclonal Antibody

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About This Item

Código UNSPSC:
12352203

origen biológico

rabbit

Nivel de calidad

500

tipo de anticuerpo

primary antibodies

clon

MRQ-72, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions

envase

vial of 0.1 mL concentrate (487R-94)
vial of 0.1 mL concentrate (487R-94-RUO) Research Use Only
vial of 0.5 mL concentrate (487R-(95)
vial of 1.0 mL (concentrate (487R-96))
vial of 1.0 mL concentrate (487R-96-RUO) Research Use Only
vial of 1.0 mL pre-dilute (487R-97-RUO) Research Use Only
vial of 1.0 mL pre-dilute ready-to-use (487R-97)
vial of 7.0 mL pre-dilute ready-to-use (487R-98)
vial of 7.0 mL pre-dilute ready-to-use (487R-98-RUO) Research Use Only

fabricante / nombre comercial

Cell Marque®

isotipo

IgG

control

pancreas

visualización

cytoplasmic, nuclear

Descripción general

Mothers Against Decapentaplegic Homolog 4 (SMAD4) is a transcription factor that is involved in TGFβ signalling pathways and acts as a tumor suppressor. SMAD4 is commonly expressed in a variety of cancers, including pancreatic ductal adenocarcinoma (PDA), colorectal carcinoma (CRC), hepatocellular carcinoma (HCC), and gastric carcinomas, as well as non-neoplastic liver, pancreas, and colon. However, a loss of expression has been observed in a subset of PDA, CRC, and gastric carcinomas due to a variety of mutations including nonsense, missense, deletions, and splice site changes. In contrast, SMAD4 is over-expressed in HCC compared to the weak expression that is exhibited in the non-neoplastic liver.

Calidad

IVD - MQ500

RUO - MQ100

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparación

Download the IFU specific to your product lot and format

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Otras notas

For Technical Service please contact: 800-665-7284 or email: [email protected]

Información legal

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

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Certificados de análisis (COA)

Lot/Batch Number
0000399572
0000399572

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Michael Torbenson et al.
Human pathology, 33(9), 871-876 (2002-10-16)
In the normal liver, the transforming growth factor beta (TGF-beta) signaling pathway plays an important role in inhibiting hepatocyte growth. This effect is mediated through Smad4 (or Dpc4), a tumor-suppressor gene that affects gene transcription and controls cell growth. A
K L Woodford-Richens et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(17), 9719-9723 (2001-08-02)
Loss of chromosome 18q21 is well documented in colorectal cancer, and it has been suggested that this loss targets the DCC, DPC4/SMAD4, and SMAD2 genes. Recently, the importance of SMAD4, a downstream regulator in the TGF-beta signaling pathway, in colorectal
Y H Kim et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 15(4), 574-580 (2004-03-23)
Transforming growth factor-beta (TGF-beta) modulates the growth and function of many cells, including those with malignant transformation. Smad proteins have been identified as major components in the intracellular signaling of TGF-beta family members. To clarify the correlations between clinicopathologic profiles
R Salovaara et al.
Gut, 51(1), 56-59 (2002-06-22)
Loss of DNA sequences from chromosome 18q21 is a major genetic change in colorectal tumorigenesis. Multiple genes have been identified in this area. One of these, DPC4 (deleted in pancreatic cancer 4, also known as SMAD4), is mutated in a
Lauren L Ritterhouse et al.
Histopathology, 75(4), 546-551 (2019-05-06)
SMAD4 (DPC4) is a tumour suppressor gene that is dysregulated in various tumour types, particularly pancreaticobiliary and gastrointestinal carcinomas. Corresponding loss of protein expression has been reported in approximately 50% of pancreatic and 25% of colonic adenocarcinomas. In the evaluation
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