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Sigma-Aldrich

Sulfato de dextrano sodium salt

Mr ~40,000

Sinónimos:

DSS Dextrán sulfato sódico

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5 G
US$ 225,00
25 G
US$ 862,00
100 G
US$ 2.550,00

US$ 225,00

Fecha estimada de envío03 de abril de 2025

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5 G
US$ 225,00
25 G
US$ 862,00
100 G
US$ 2.550,00

About This Item

UNSPSC Code:
12352201
NACRES:
NA.25

US$ 225,00

Fecha estimada de envío03 de abril de 2025

Solicitar un pedido a granel

form

powder

Quality Level

100

mol wt

Mr ~40,000

loss

≤10% loss on drying

color

white to off-white

useful pH range

6.0-8 (10 g/L)

mp

(Decomposes on heating.)

solubility

water: soluble

storage temp.

room temp

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General description

El dextrano es un polímero de anhidroglucosa. Está compuesto aproximadamente por un 95% de enlaces alfa-D-(166). El resto de los enlaces (163) corresponden a las ramificaciones del dextrano.

Application

El dextrán sulfato se utiliza habitualmente para precipitación selectiva de lipoproteínas, sonda de hibridación de ADN inmovilizado en membrana, liberación del ADN de los complejos ADN-histonas e inhibición de la unión del ARN a los ribosomas.

Biochem/physiol Actions

El tratamiento con dextrán sulfato de sodio desencadena el desarrollo de colitis en ratones y ratas al unirse a los ácidos grasos de longitud de cadena intermedia en el colon e inducir inflamación. [1]

Other Notes

Si desea conocer por completo nuestra amplia gama de dextranos para su investigación, le recomendamos que visite nuestra página de categoría Carbohidratos .

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
BCCM3019
BCCL8105
BCCK7265
0000274351
0000273421

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Li Cao et al.
International immunopharmacology, 72, 264-274 (2019-04-21)
Extracellular vesicles (EVs) secreted by bone marrow mesenchymal stem cells (BMSCs) have shown repairing effects in tissue damage. However, their efficacy and mechanism in the treatment of ulcerative colitis (UC), a type of chronic inflammatory bowel disease, are unclear. To
Andrey V Markov et al.
Molecules (Basel, Switzerland), 25(10) (2020-05-28)
Semi-synthetic triterpenoids, bearing cyano enone functionality in ring A, are considered to be novel promising therapeutic agents with complex inhibitory effects on tissue damage, inflammation and tumor growth. Previously, we showed that the cyano enone-containing 18βH-glycyrrhetinic acid derivative soloxolone methyl
Hamed Laroui et al.
PloS one, 7(3), e32084-e32084 (2012-03-20)
Inflammatory bowel diseases (IBDs), primarily ulcerative colitis and Crohn's disease, are inflammatory disorders caused by multiple factors. Research on IBD has often used the dextran sodium sulfate (DSS)-induced colitis mouse model. DSS induces in vivo but not in vitro intestinal
Yueqin He et al.
Scientific reports, 10(1), 10180-10180 (2020-06-25)
CD47 deficient mice are resistant to dextran sulfate sodium (DSS)-induced experimental colitis. The underlying mechanism, however, remains incompletely understood. In this study, we characterized the role of CD47 in modulating homeostasis of gastrointestinal tract. We found that CD47 expression in
N Facchinello et al.
Scientific reports, 7(1), 4371-4371 (2017-07-01)
Glucocorticoids (GCs) play important roles in developmental and physiological processes through the transcriptional activity of their cognate receptor (Gr). Using CRISPR/Cas9 technology, we established a zebrafish null Gr mutant line and compared its phenotypes with wild type and a zebrafish
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Questions

1–4 of 4 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Does DDS (Dextran Sodium Sulfate) come in a USP grade for a animal studies?

    1 answer

    1. Unfortunately, there is no pharmaceutical grade Dextran Sodium Sulfate available at this time. This product is not tested for use in animal models. It would be up to the researcher to determine suitability.

      Helpful?

  4. Hello! I want to know if you can autoclave water with 4% of dextran sulfate sodium (DSS) without decomposing the DSS.

    1 answer

    1. The solubility of dextran sulfates is tested at 100 mg/mL in water. Clear solutions are obtained. Buffered aqueous dextran sulfate solutions can be sterilized by autoclaving at 110-115 °C for 30 to 45 minutes. Dextran can be hydrolyzed by strong acids at high temperatures. Dextran sulfate has a higher affinity for calcium ions than for sodium ions. The calcium salt of dextran sulfate is insoluble. The free acid (hydrogen) form of dextran sulfate is extremely acidic and autohydrolyzes rapidly in solution and as a powder.

      More information can be found here: https://www.sigmaaldrich.com/technical-documents/protocol/protein-biology/protein-pulldown/dextran-sulfate

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