Based on the information available, this version does recognize the epsilon subunit. This conclusion is drawn from the fact that the CD3 epsilon, also known as the cytoplasmic CD3 antibody, exhibits a cytoplasmic staining pattern with perinuclear Golgi accentuation and very rarely membranous. Typically, this antibody is utilized for identifying T cell and NK cell lymphomas in FFPE tissues (please refer to representative staining photos). While the Cd3 surface antibody is commonly used in flow cytometry for membranous CD3 detection, the CD3 epsilon cytoplasmic is generally used in FFPE tissue, as is often done for IHC.
103R-9
CD3 (MRQ-39) Rabbit Monoclonal Antibody
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
En este momento no podemos mostrarle ni los precios ni la disponibilidad
Productos recomendados
origen biológico
rabbit
Nivel de calidad
100
500
conjugado
unconjugated
forma del anticuerpo
culture supernatant
tipo de anticuerpo
primary antibodies
clon
MRQ-39, monoclonal
descripción
For In Vitro Diagnostic Use in Select Regions (See Chart)
Formulario
buffered aqueous solution
reactividad de especies
human
envase
pkg of 0.1 mL concentrate (103r-94)
pkg of 0.5 mL concentrate (103R-95)
pkg of 1.0 mL concentrate (103R-96)
pkg of 1.0 mL predilute (103R-97)
pkg of 7.0 mL predilute (103R-98)
fabricante / nombre comercial
Cell Marque®
DIV
for in vitro diagnostic use
técnicas
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)
isotipo
IgG1
control
tonsil
Condiciones de envío
wet ice
temp. de almacenamiento
2-8°C
visualización
membranous
Información sobre el gen
human ... CD3E(916)
Categorías relacionadas
Descripción general
Anti-CD3 has been considered the best all around T-cell marker. This antibody reacts with an antigen present in early thymocytes. The positive staining of this marker may represent a sign of early commitment to the T-Cell lineage.
Calidad
 IVD |  IVD |  IVD |  RUO |
Ligadura / enlace
CD3 Positive Control Slides, Product No. 103S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Forma física
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Nota de preparación
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Otras notas
For Technical Service please contact: 800-665-7284 or email: [email protected]
Información legal
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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SM Denning, et al.
Leucocyte Typing III, 144-147 (1987)
E A Clark et al.
Immunology today, 10(7), 225-228 (1989-07-01)
During 1987, striking advances were made in defining the receptors and ligands for cell-to-cell adhesion interactions involving leukocytes. In 1988, two major leukocyte differentiation antigens, CD10 (cALLA) and CD45 (LCA, T200), were shown to be enzymes while two other markers
Ahmet Dogan et al.
The American journal of surgical pathology, 27(7), 903-911 (2003-06-27)
Occasionally, primary large B-cell lymphomas (LBLs) arising in the spleen present with a micronodular pattern involving the splenic white pulp but sparing the red pulp. Histologically, the nodules contain scattered large B cells in a background of numerous T cells
Ulla Axdorph et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 110(5), 379-390 (2002-06-22)
Morphologically, T-cell-rich B-cell lymphoma (TCRB-NHL) may be indistinguishable from Hodgkin's disease (HD). Immunophenotyping may be helpful in the separation of these entities. TCRB-NHL is occasionally misdiagnosed and treated as HD. However, information is limited regarding clinical characteristics and outcome of
P C Beverley et al.
European journal of immunology, 11(4), 329-334 (1981-04-01)
The properties of human lymphocyte fractions isolated either by sheep red cell(E) rosetting or by fluorescence-activated cell sorting after staining with UCHT1 monoclonal anti-T cell antibody have been compared. Two populations of E+ cells with very different phenotype and function
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Could you confirm if the CD3 clone (Catalog #103R-96) recognizes epsilon?
1 answer-
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