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PHR1176

Supelco

Tryptophan

Pharmaceutical Secondary Standard; Certified Reference Material

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1 G
US$ 185,00

US$ 185,00

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1 G
US$ 185,00

About This Item

Número de CAS:
Número CE:
Código UNSPSC:
41116107
eCl@ss:
32160406
NACRES:
NA.24

US$ 185,00

PRECIOS SIN IMPUESTOS NACIONALES

Disponible para envío el11 de abril de 2025Detalles


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grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

Agency

traceable to Ph. Eur. T2610000
traceable to USP 1700501

familia API

tryptophan

CofA

current certificate can be downloaded

técnicas

HPLC: suitable
gas chromatography (GC): suitable

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-30°C

cadena SMILES

[nH]1c2c(c(c1)CC(N)C(=O)O)cccc2

InChI

1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)

Clave InChI

QIVBCDIJIAJPQS-UHFFFAOYSA-N

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Descripción general

Tryptophan is an essential amino acid and a precursor for the synthesis of serotonin (5-HT), a neuromodulator responsible for modulating sleep and appetite regulation.[1][2]

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

Aplicación

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Tryptophan may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric techniques.[3][4]

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAB2382 in the slot below. This is an example certificate only and may not be the lot that you receive.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Aplicación

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Certificados de análisis (COA)

Lot/Batch Number

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The use of carbon paste electrode in the direct voltammetric determination of tryptophan in pharmaceutical formulations
Fiorucci AR, et al.
Journal of Pharmaceutical and Biomedical Analysis, 28(5), 909-915 (2002)
Tryptophan supplementation modulates social behavior: a review
Steenbergen L, et al.
Neuroscience and Biobehavioral Reviews, 64, 346-358 (2016)
Evolution of tryptophan and its foremost metabolites? concentrations in milk and fermented dairy products
Bertazzo A, et al.
PharmaNutrition, 4(2), 62-67 (2016)
Differential spectrophotometric determination of tyrosine and tryptophan in pharmaceutical amino acid solutions
Demeester J, et al.
Journal of Pharmaceutical Sciences, 67(5), 729-730 (1978)
Saara Ahmad et al.
JPMA. The Journal of the Pakistan Medical Association, 63(1), 65-68 (2013-07-20)
To investigate the relationship between plasma tryptophan and the occurrence of memory dysfunctions in male and female type 1 diabetics. The case-control study was conducted at two urban healthcare facilities in Karachi from January to June 2009, and comprised 100

Questions

1–3 of 3 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. Il prodotto cod.PHR1176 è identificato come CRM ma non ho trovato nel certificato il riferimento alla certificazione ISO 17034 per il prodotto, a differenza del cod. 51145 dove viene riportata. Chiedo se realmente sono entrambe CRM secondo ISO17034?

    1 answer
    1. The Certified Reference Materials currently available are ISO17034 Certified. This information is referenced on the lot-specific Certificate of Analysis, in the Accreditation section. Please see the link below to review a sample or lot-specific Certificate:
      https://www.sigmaaldrich.com/product/sial/phr1176#product-documentation

      Please see the following link to review the site ANAB Certificate of Accreditation:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/266/955/iso17025-cert-scopev010-july26.pdf

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