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B5899

Supelco

Buflomedil hydrochloride

analytical standard

Sinónimos:

4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone

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About This Item

Fórmula empírica (notación de Hill):
C17H25NO4 · HCl
Número de CAS:
35543-24-9
Peso molecular:
343.85
EC Number:
252-611-9
MDL number:
MFCD00078965
UNSPSC Code:
41116107
PubChem Substance ID:
329773268
NACRES:
NA.24

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

Cl.COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1

InChI

1S/C17H25NO4.ClH/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18;/h11-12H,4-10H2,1-3H3;1H

InChI key

ZDPACSAHMZADFZ-UHFFFAOYSA-N

Gene Information

human ... EBP(10682)

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General description

Buflomedil hydrochloride is a vasoactive agent. Its mode of action involves increasing the peripheral and cerebral blood flow in ischaemic tissues of patients, who are mostly affected with vascular diseases.[1]

Application

Buflomedil hydrochloride may be used as an analytical standard for the determination of buflomedil in biological matrices using high-performance liquid chromatography technique.[2] It may also be used as an analytical reference standard for the quantification of the analyte in pharmaceutical formulations and serum samples using electroanalytical and chromatographic techniques.[1]
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number

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Tine L M de Backer et al.
The Cochrane database of systematic reviews, 3(3), CD000988-CD000988 (2013-04-02)
Intermittent claudication (IC) is pain caused by chronic occlusive arterial disease, that develops in a limb during exercise and is relieved with rest. Buflomedil is a vasoactive agent used to treat peripheral vascular disease. However, its clinical efficacy for IC
F Loisel et al.
Chirurgie de la main, 29(5), 326-331 (2010-05-11)
Antithrombotic agents are not routinely used in microsurgery for finger replantation. A prospective monocentric study of 13 cases of replantation at hand level is reported with local irrigation of anastomosis with urokinase and low-molecular-weight heparin. Thirteen consecutive patients have been
D Tsantilas et al.
International angiology : a journal of the International Union of Angiology, 28(3), 170-174 (2009-01-29)
Our understanding of vascular pathophysiology has significantly improved during the past two decades. Patients with type 2 diabetes mellitus have an increased vascular risk and a series of modifiable risk factors play a crucial role in the atherosclerotic process. The
Laurent Bourguignon et al.
Fundamental & clinical pharmacology, 26(2), 279-285 (2011-10-19)
Population pharmacokinetics and simulation techniques currently play an important role in new drug development. This paper illustrates the potential value of those methods in postmarketing safety assessment, using buflomedil in elderly patients as an example. We retrospectively assessed the risk
Denise Salles Coelho da Mota et al.
Clinics (Sao Paulo, Brazil), 64(8), 797-802 (2009-08-20)
This study investigated the effects of buflomedil and pentoxifylline, both of which are used in reconstructive surgery of hamster skin flap microcirculation, and evaluated the skin flap survival rate by orthogonal polarization spectral imaging. Twenty-four adult male Syrian golden hamsters
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