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Merck

45661

Supelco

Strychnine

PESTANAL®, analytical standard

Sinónimos:

(−)-Strychnine

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About This Item

Fórmula empírica (notación de Hill):
C21H22N2O2
Número de CAS:
Peso molecular:
334.41
Beilstein/REAXYS Number:
52979
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:

grade

analytical standard

Quality Level

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

284-286 °C (lit.)

application(s)

agriculture
cleaning products
cosmetics
environmental
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)

format

neat

SMILES string

[H][C@@]12CC(=O)N3c4ccccc4[C@]56CC[N@H]7CC(=CCO1)[C@]([H])(C[C@@H]57)[C@]2([H])[C@]36[H]

InChI

1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1

InChI key

QMGVPVSNSZLJIA-FVWCLLPLSA-N

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General description

Strychnine is an alkaloid, available as a bioactive component in Semen Strychni, exhibiting analgesic, anti-inflammatory and anti-tumor effects. It is widely used in neurological research, treatment of genetic disorder nonketotic hyperglycinemia, treatment of stomach ailments, etc.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Strychnine may be used as an analytical reference standard for the quantification of the analyte in biological samples using liquid chromatography coupled to electrospray ionization mass spectrometry.

Biochem/physiol Actions

Produce convulsiones; antagonista en los receptores de glicina no competitivo con el receptor NMDA.

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbonesEnvironment

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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Certificados de análisis (COA)

Lot/Batch Number

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Visite la Librería de documentos

The 100 Most Important Chemical Compounds: A Reference Guide (2005)
Application of solid phase microextraction to the determination of strychnine in blood
Borroso.M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 816(1-2), 29-34 (2005)
Determination of strychnine and brucine in rat plasma using liquid chromatography electrospray ionization mass spectrometry
Xu Y, et al.
Journal of Pharmaceutical and Biomedical Analysis, 49(2), 487-491 (2009)
Susanne Jonsson et al.
Neuropharmacology, 82, 69-75 (2014-04-02)
The ability of drugs of abuse to increase mesolimbic levels of dopamine is a characteristic associated with their rewarding effects. Exactly how these effects are produced by different substances is not as well characterised. Our previous work in rats has
Yan Lu et al.
The Journal of clinical investigation, 123(9), 4050-4062 (2013-08-28)
Neuropathic pain is characterized by mechanical allodynia induced by low-threshold myelinated Aβ-fiber activation. The original gate theory of pain proposes that inhibitory interneurons in the lamina II of the spinal dorsal horn (DH) act as "gate control" units for preventing

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