SCC624

Lacun.3 Mouse Lung Adenocarcinoma Cell Line

• Sinónimos: Lacun-3, Lacun3
• Código UNSPSC: 41106514

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• envase: vial of ≥1X10⁶ vial
• fabricante / nombre comercial: Millipore
• técnicas: cell culture | mammalian: suitable
• Condiciones de envío: liquid nitrogen
• temp. de almacenamiento: −196°C

Descripción

Aplicación

• Each vial contains > 1X10⁶ viable cells.
• Cells are tested negative for infectious diseases by a Essential CLEAR Panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for interspecies contamination from human, rat, Chinese hamster, Golden Syrian hamster, and nonhuman primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
• Cells are negative for mycoplasma contamination.

Características y beneficios

Lacun.3 cells are capable of forming spheroids that can be maintained over multiple passages and display increased cancer stem cell characteristics including increased ALDH activity.

Descripción de destino

Recent cancer research often studies a newly characterized type of cell referred to as cancer stem cells (CSCs) or also sometimes termed tumor-initiating cells (TICs.) These cells appear to have significant capabilities to grow, differentiate, generate tumors and resist chemotherapy. Tumor sphere cultures (TSCs) have emerged as a new format of studying cancer as well as understanding CSCs. The spheroid structures of TSCs appear to induce stem-like characteristics evidenced by the increased expression of stem cell markers. This 3D spheroid structure is also a much more accurate way to mimic the behavior of a solid tumor which develops in 3-dimensions and behaves quite differently from a monolayer cell culture. Spheroids are understood to have more tumor-forming capabilities when compared to monolayer cultures, yet the underlying mechanism for these characteristics is still under study. Stem-cell like properties, such as increased aldehyde dehydrogenase activity (ALDH), have already been used to identify CSCs in a variety of cancer types.

Almacenamiento y estabilidad

Lacun.3 cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages without significantly affecting cell marker expression and function.

Otras notas

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact [email protected].

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable