SCC132M
CCMCL1 Mantle Cell Lymphoma Cell Line
Human
About This Item
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product name
CCMCL1 Mantle Cell Lymphoma Cell Line, CCMCL1 human mantle cell lymphoma cell line is well characterized at the molecular level and can support research and drug development efforts targeting MCL.
biological source
human
Quality Level
technique(s)
cell culture | mammalian: suitable
General description
CCMCL1 has the IGH-CCND1 genetic hallmark of MCL and closely resembles the terminal-phase leukemic MCL cells as evidenced by immunophenotyping, karyotyping, IGHV sequence, and whole exome sequencing (WES) (1). WES provides unbiased, direct evidence for conservation of the MCL genome in CCMCL1 at single-nucleotide resolution. WES detected no mutation in genes of the B-cell receptor or phosphatidylinositol 3-kinase pathway, including BTK and AKT. However, CCMCL1 constitutively expressed phosphorylated AKT and BTK, suggesting CCMCL1 is an appropriate model for studies targeting these two pathways in MCL. Other MCL cell lines have mutations or deletions in either ATM or TP53; with this respect CCMCL1 also offers an opportunity for MCL studies without the interference of ATM or TP53 loss.
Reference:
1. Zhao X, Chen-Kiang S, Shetty S, Di Liberto M, Bodo J, Durkin L, Eng K, Elemento O, Smith MR, Hsi ED (2015) CCMCL1: a new model of aggressive mantle cell lymphoma. Blood 125(17): 2730-2732.
Cell Line Description
Application
Cancer
Oncology
Quality
• Cells are tested negative for Epstein-Barr virus, HPV-16, HPV-18, Hepatitis A, C, Herpesvirus type 6, 7, 8 and HIV-1 & 2 viruses by PCR
• Cells are negative for mycoplasma contamination.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line
Disclaimer
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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