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MAB5460

Sigma-Aldrich

Anti-Nkx2.1 Antibody, clone 8G7-G3-1

ascites fluid, clone 8G7-G3-1, Chemicon®

Sinónimos:

TTF-1, Thyroid Transcription Factor-1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

ascites fluid

antibody product type

primary antibodies

clone

8G7-G3-1, monoclonal

species reactivity

human

packaging

antibody small pack of 25 μL

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_001079668.1
NM_003317.3

UniProt accession no.

P43699

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NKX2-1(7080)

Specificity

Nkx2.1 (Thyroid Transcription Factor-1, TTF-1).

Immunogen

Recombinant rat Nkx2.1.

Application

This Anti-Nkx2.1 Antibody is validated for use in WB, IH(P) for the detection of Nkx2.1.
Western blot. The antibody reacts with a 40 kDa band in immunoblots of nuclear extracts or whole cell lysates from the Nkx2.1 positive cell lines MLE15, H441-4, H345 and rat type II pmeumocyte cells.

Immunohistochemistry. The antibody can be used on formalin-fixed paraffin embedded tissue. Heat induced epitope retrieval is recommended.

Optimal working dilutions must be determined by end user.

Quality

Tested

Other Notes

Please refer to lot specific datasheet.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

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Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Yan Liu et al.
Nature biotechnology, 31(5), 440-447 (2013-04-23)
Dysfunction of basal forebrain cholinergic neurons (BFCNs) and γ-aminobutyric acid (GABA) interneurons, derived from medial ganglionic eminence (MGE), is implicated in disorders of learning and memory. Here we present a method for differentiating human embryonic stem cells (hESCs) to a
Weronika Szadzinska et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(44), 9129-9140 (2021-09-15)
In contrast to easily formed fear memories, fear extinction requires prolonged training. The prelimbic cortex (PL), which integrates signals from brain structures involved in fear conditioning and extinction such as the ventral hippocampus (vHIP) and the basolateral amygdala (BL), is
Zhenyu Chen et al.
Stem cell reports, 11(5), 1257-1271 (2018-11-20)
It is highly desirable to specify human developmental principles in an appropriate human model with advanced genetic tools. However, genetically engineering human cells with lineage-tracing systems has not been achieved. Here we introduce strategies to construct lineage-tracing systems in human
Xinyu Chen et al.
PLoS biology, 20(11), e3001868-e3001868 (2022-11-18)
The striatum links neuronal circuits in the human brain, and its malfunction causes neuronal disorders such as Huntington's disease (HD). A human striatum model that recapitulates fetal striatal development is vital to decoding the pathogenesis of striatum-related neurological disorders and
Saaket Varma et al.
American journal of physiology. Lung cellular and molecular physiology, 306(5), L405-L419 (2014-01-01)
Chronic injury of alveolar lung epithelium leads to epithelial disintegrity in idiopathic pulmonary fibrosis (IPF). We had reported earlier that Grhl2, a transcriptional factor, maintains alveolar epithelial cell integrity by directly regulating components of adherens and tight junctions and thus
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