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AB9682

Sigma-Aldrich

Anti-Dardarin Antibody

serum, Chemicon®

Sinónimos:

LRRK2 Leucine-rich repeat kinase 2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_198578.2

UniProt accession no.

Q5S007

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... LRRK2(120892)

Specificity

Recognizes LRRK2 [leucine-rich repeat kinase 2, Dardarin]. By Western blot the antibody recognizes a band at ~240 kDa in mouse brain extract. An additional band at ~130-140 kDa can also be seen. On human brain lysate the antibody recognizes a band at ~150 kDa.

Immunogen

Synthetic peptide from rat LRRK2.

Application

Anti-Dardarin Antibody detects level of Dardarin & has been published & validated for use in ELISA & WB.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Western blot: 1:5,000-1:10,000 on mouse brain extract.

Optimal working dilutions must be determined by the end user.

Target description

286 kDa

Physical form

Rabbit Serum. Liquid.
Unpurified

Storage and Stability

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Analysis Note

Control
Brain tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Izabella D Greene et al.
Journal of neuroscience research, 92(4), 506-516 (2014-01-01)
Mutations in the leucine-rich repeat kinase 2 (lrrk2) gene are the leading genetic cause of Parkinson's disease (PD). In characterizing the novel ROC domain mutant A1442P, we compared its steady-state protein levels, propensity to aggregate, and toxicity with the pathogenic
Berta Pons et al.
Oncology reports, 27(1), 225-231 (2011-09-17)
Translational control is a crucial component of cancer development and progression. Eukaryotic initiation factor (eIF) 4E mediates eIF4F association with the mRNA
Saskia Biskup et al.
BMC neuroscience, 8, 102-102 (2007-11-30)
Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene account for a significant proportion of autosomal-dominant and some late-onset sporadic Parkinson's disease. Elucidation of LRRK2 protein function in health and disease provides an opportunity for deciphering molecular pathways important in

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