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Key Documents

AB5561

Sigma-Aldrich

Anti-GABA A Receptor β2 Antibody, cytoplasmic loop

Chemicon®, from rabbit

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, mouse, bovine, human

manufacturer/tradename

Chemicon®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... GABRB2(2561)

Specificity

GABAA receptor beta2 subunit. The antibody is specific for the ~50 to 56kDa in rat brain membrane fractions.

Immunogen

MBP fusion protein from the cytosolic loop of rat GABAA receptor beta2 subunit.

Application

Anti-GABA A Receptor β2 Antibody, cytoplasmic loop is an antibody against GABA A Receptor β2 for use in IP & WB.
Western blot: 1:1,000

Immunopreciptation: The antibody will immunoprecipitate 68% of all GABAA receptors in dodecylsulfate extracts of rat forebrains (150 μL) using 15 μg of antibody.

Optimal working dilutions must be determined by the end user.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2


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Evangelos Sotiriou et al.
Journal of neuroscience research, 82(5), 690-700 (2005-11-08)
Recent data demonstrate weaker gamma-aminobutyric acid (GABA)-ergic inhibition in ventral (VH) compared with dorsal (DH) hippocampus. Therefore, we examined possible differences regarding the GABAA receptors between VH and DH as follows: 1) the expression of the GABAA receptor subunits (alpha1/2/4/5
GABA(A) receptor alpha1 subunit mutation A322D associated with autosomal dominant juvenile myoclonic epilepsy reduces the expression and alters the composition of wild type GABA(A) receptors.
Ding, L; Feng, HJ; Macdonald, RL; Botzolakis, EJ; Hu, N; Gallagher, MJ
The Journal of Biological Chemistry null
Bobae An et al.
eLife, 6 (2017-07-04)
There has been a longstanding debate on whether original fear memory is inhibited or erased after extinction. One possibility that reconciles this uncertainty is that the inhibition and erasure mechanisms are engaged in different phases (early or late) of extinction.
George E Farmer et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 315(5), R972-R982 (2018-08-30)
The median preoptic nucleus (MnPO) is an integrative site involved in body fluid homeostasis, cardiovascular control, thermoregulation, and sleep homeostasis. Angiotensin II (ANG II), a neuropeptide shown to have excitatory effects on MnPO neurons, is of particular interest with regard
Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome.
Zhou, C; Huang, Z; Ding, L; Deel, ME; Arain, FM; Murray, CR; Patel, RS; Flanagan, CD; Gallagher, MJ
The Journal of Biological Chemistry null

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