648450-M

TrkA Inhibitor

The TrkA Inhibitor, also referenced under CAS 388626-12-8, controls the biological activity of TrkA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinónimos: TrkA Inhibitor
• Fórmula empírica (notación de Hill): C₁₅H₁₃N₃O₃S
• Número de CAS: 388626-12-8
• Peso molecular: 315.35
• UNSPSC Code: 12352200

Propiedades

• assay: ≥97% (sum of two isomers, HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 200 mg/mL
• storage temp.: 2-8°C

Descripción

General description

A potent, cell-permeable, reversible, and highly selective inhibitor of TrkA (IC₅₀ = 63 nM), presumably by targeting the ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.

An oxindole compound that acts as a cell-permeable, reversible, potent, and highly selective inhibitor of TrkA (IC₅₀ = 63 nM), presumably by targeting the kinase’s ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.

Biochem/physiol Actions

Primary Target
TrkA

Target IC₅₀: 63 nM against TrkA

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Wood, E.R., et al. 2004. Bioorg. Med. Chem. Lett.14, 953.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable