565761

γ-Secretase Inhibitor IV

The γ-Secretase Inhibitor IV controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Sinónimos: γ-Secretase Inhibitor IV, 2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal
• Fórmula empírica (notación de Hill): C₂₅H₂₆N₂O₃
• Peso molecular: 402.49
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: lyophilized solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: DMSO: 10 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C

Descripción

Descripción general

A cell-permeable, reversible inhibitor of γ-secretase. Equipotently inhibits the release of Aβ_x-40 (ED₅₀ = 2.6 µM) and Aβ_x-42 (ED₅₀ = 2.7 µM) in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

ED50 = 2.6 µM for Aβx-40

Primary Target
Aβ_x-40

Product does not compete with ATP.

Reversible: yes

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Secuencia

2-Naphthoyl-Val-Phe-CHO

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Green, K.N., et al. 2002. J. Physiol.541.3, 1013.
Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA96, 11049.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable