528120

PIPER - CAS 213416-70-7 - Calbiochem

A perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA.

• Sinónimos: PIPER - CAS 213416-70-7 - Calbiochem, N,Nʹ- bis[2-(1-Piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, Telomerase Inhibitor IV, N,Nʹ-bis[2-(1-Piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, Telomerase Inhibitor IV
• Fórmula empírica (notación de Hill): C₃₈H₃₆N₄O₄
• Número de CAS: 213416-70-7
• Peso molecular: 612.72
• Código UNSPSC: 12352200

Propiedades

• Ensayo: ≥95% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: dark purple
• solubilidad: 5% acetic acid: 50 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C

Descripción

Descripción general

A perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA. The strongest binding site for PIPER appears to be the 3′-boundary of the G-quadruplex. Can also bind non-specifically to nucleic acids. May also be useful as an antiproliferative agent.

A perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA. The strongest binding site for PIPER appears to be the 3′-boundary of the G-quadruplex. Can also bind non-specifically to nucleic acids. May be useful as an antiproliferative agent.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
human telomerase

Product does not compete with ATP.

Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Otras notas

Han, H., et al. 1999. Biochemistry38, 6981.
Fedoroff, O.Y., et al. 1998. Biochemistry 37, 12367.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable