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260575

Sigma-Aldrich

1-Deoxymannojirimycin, Hydrochloride

A specific α-mannosidase I inhibitor that blocks conversion of high mannose to complex oligosaccharides.

Sinónimos:

1-Deoxymannojirimycin, Hydrochloride, DMJ, 1,5-Dideoxy-1,5-imino-D-mannitol, HCl

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About This Item

Fórmula empírica (notación de Hill):
C6H13NO4 · xHCl
Número de CAS:
84444-90-6
Peso molecular:
163.17 (free base basis)
UNSPSC Code:
12352200

Quality Level

100

assay

≥98% (TLC)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

ethanol: 1 mg/mL
water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m1/s1

InChI key

LXBIFEVIBLOUGU-KVTDHHQDSA-N

General description

A specific α-mannosidase I inhibitor that blocks conversion of high mannose to complex oligosaccharides.
Special α-mannosidase I inhibitor that blocks conversion of high mannose to complex oligosaccharides.

Biochem/physiol Actions

Cell permeable: no
Primary Target
α-mannosidase-I
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 6 months at -20°C.

Other Notes

Suzuki, S.S., and Piette, L.H. 1993. J. Cell. Biochem.51, 181.
Fuhrmann, U., et al. 1984. Nature307, 755.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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U Fuhrmann et al.
Nature, 307(5953), 755-758 (1984-02-23)
Many secretory and membrane proteins are glycoproteins carrying asparagine-linked (N-linked) oligosaccharides. There are two types of N-linked glycans, referred to as high-mannose and complex type, respectively. Biosynthesis of N-linked glycans of the complex type proceeds via a high-mannose intermediate. After
S S Suzuki et al.
Journal of cellular biochemistry, 51(2), 181-189 (1993-02-01)
The mouse embryo fibroblast cell line, C3H/10T1/2, synthesized and deposited a large amount of fibronectin especially in the pericellular matrix. Confluent cultures of these cells cultured in the presence of 0.3 micrograms/ml of retinyl acetate released cell surface fibronectin and

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