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Merck

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2011

Bilirubin

solid, bile pigment, Calbiochem®

Sinónimos:

Bilirubin

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Fórmula empírica (notación de Hill):
C33H36N4O6
Número CAS:
Peso molecular:
584.66
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
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Nombre del producto

Bilirubin, Principal pigment of bile and one of the major end products of hemoglobin decomposition.

Quality Level

description

RTECS - DU3038000
Merck USA index - 14, 1218

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

red-brown

solubility

chloroform: 1 mg/mL, alkaline solution: soluble

shipped in

ambient

storage temp.

10-30°C

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Este artículo
B4126NIST916B14370
Bilirubin NIST®SRM®

NIST916B

Bilirubin

form

solid

form

powder

form

-

form

powder

Quality Level

100

Quality Level

300

Quality Level

-

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

NIST®

manufacturer/tradename

-

storage temp.

10-30°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

solubility

chloroform: 1 mg/mL, alkaline solution: soluble

solubility

aqueous acid: soluble, aqueous base: soluble, benzene: soluble, chloroform: soluble

solubility

-

solubility

-

storage condition

OK to freeze, protect from light

storage condition

-

storage condition

-

storage condition

-

General description

Bilirubin is an orange-yellow bile pigment[1] and one of the major end products of hemoglobin decomposition.[2] It contains conjugated double bonds and reactive hydrogen atoms. In adults, the upper limit of the normal range of bilirubin is >1mg/dL.[3] Serum levels of bilirubin in healthy newborns are less than 15 mg/dl.[4] This product corresponds to the unconjugated form.

Biochem/physiol Actions

Bilirubin is reported to cross the blood-brain barrier and exert significant antioxidant effects in the brain. This pigment aids in coloration in the various forms of jaundice.[1] Bilirubin levels act as biomarkers in liver and blood disorders.[5] Unconjugated form of bilirubin at lower levels serves as a physiological antioxidant.[2][5] However, increased concentration of bilirubin is toxic and leads to neonatal hyperbilirubinemia in neonates.[5]

Preparation Note

Unstable in basic solutions; reconstitute just prior to use.

Other Notes

Extinction coefficient (454 nm, CHCl3):59,100-62,300 M-1cm-1.
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary Target

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Jürgen Reingruber et al.
The Journal of physiology, 598(17), 3747-3763 (2020-06-20)
Most vertebrate eyes have rods for dim-light vision and cones for brighter light and higher temporal sensitivity. Rods evolved from cone-like precursors through expression of different transduction genes or the same genes at different expression levels, but we do not
R Stocker et al.
Science (New York, N.Y.), 235(4792), 1043-1046 (1987-02-27)
Bilirubin, the end product of heme catabolism in mammals, is generally regarded as a potentially cytotoxic, lipid-soluble waste product that needs to be excreted. However, it is here that bilirubin, at micromolar concentrations in vitro, efficiently scavenges peroxyl radicals generated
Sana Ullah et al.
Iranian journal of public health, 45(5), 558-568 (2016-07-12)
Hyperbilirubinemia, or jaundice, is a life threatening disorder in newborns. It is a multifactorial disorder with many symptoms. Generally, the physiological jaundice is the most prevalent type however in some regions pathological jaundice is also common. This review article focuses
Zeng Hong et al.
ACS omega, 5(46), 29903-29912 (2020-12-01)
The reaction of magnesium or zinc amides with alkyl or benzyl halides is an attractive approach to make C-N bonds, especially for electron-poor organic halides. The magnesium-promoted preparation of hindered non-nucleophilic amine (N,N-diisopropylethylamine) from ethyl chloride and zinc diisopropylamide has
Elisabeth Lobner et al.
Frontiers in bioengineering and biotechnology, 8, 49-49 (2020-03-03)
The transmembrane protein CD19 is exclusively expressed on normal and malignant B cells and therefore constitutes the target of approved CAR-T cell-based cancer immunotherapies. Current efforts to assess CAR-T cell functionality in a quantitative fashion both in vitro and in

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