19-203
Epoxomicin Inhibitor
The Epoxomicin Inhibitor controls the biological activity of Epoxomicin. This small molecule/inhibitor is primarily used for Biochemicals applications.
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About This Item
UNSPSC Code:
12352106
eCl@ss:
32160405
NACRES:
NA.41
Productos recomendados
Quality Level
form
solid
manufacturer/tradename
Upstate®
NCBI accession no.
UniProt accession no.
shipped in
dry ice
Application
Cell permeable, potent and specific irreversible inhibitor of the proteasome. Novel mechanism of action. Blocks chymotrypsin-like, trypsin like and PGPH activities of the proteasome. Regulates antigen presentation at non-toxic doses. Displays in vivo anti-inflammatory activity in mouse ear inflammation assay and in vitro NF-kB inhibition. The product is not sterile.
Biochem/physiol Actions
Inhibitor Type: Protease Inhibitors
Protein Target: RPS27A
Storage and Stability
Store at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
Certificados de análisis (COA)
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K Schwarz et al.
Journal of immunology (Baltimore, Md. : 1950), 164(12), 6147-6157 (2000-06-08)
The complete inhibition of proteasome activities interferes with the production of most MHC class I peptide ligands as well as with cellular proliferation and survival. In this study we have investigated how partial and selective inhibition of the chymotrypsin-like activity
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