116815-M

Adenosine 3′,5′-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt

A cell-permeable cAMP analog that binds cAMP-receptor proteins.

• Sinónimos: Adenosine 3′,5′-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt, Adenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Sp, Sp-cAMPS, TEA
• Fórmula empírica (notación de Hill): C₁₀H₁₁N₅O₅PS · 4C₆H₁₆N
• Número de CAS: 71774-13-5
• Peso molecular: 753.06
• Código UNSPSC: 12352200

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: crystalline solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• solubilidad: water: 20 mg/mL
• temp. de almacenamiento: −20°C

Descripción

Descripción general

A cell-permeable cAMP analog that binds cAMP-receptor proteins. Induces the guanine-nucleotide-exchange factor activity of GEFI, also known as Epac (exchange protein directly activated by cAMP), and GEFII towards Rap1 both in vivo and in vitro. Known to cause a decrease in cytosolic pH. Note: 10 µmol = 4.47 mg. λ_max = 258 nm; ε_max = 15,000 M^-1cm-1 (pH 7..0).

Note: 10 µmol = 4.47 mg.

Acciones bioquímicas o fisiológicas

Primary Target
cAMP-receptor proteins

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.

Otras notas

Kawasaki, H., et al. 1998. Science 282, 2275.
de Rooij, J., et al. 1998. Nature 396, 474.
Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun.182, 1356.
Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28.
Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch.420, 336.
Takuma, T., and Ichida, T. 1991. J. Biochem.110, 292.
Dostmann, W.R., et al. 1990. J. Biol. Chem.265, 10484.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable