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Merck
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07-838

Sigma-Aldrich

Anti-phospho-IR (Tyr972) Antibody

Upstate®, from rabbit

Sinónimos:

Insulin Receptor, CD220

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, human

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

phosphorylation (pTyr972)

Gene Information

human ... INSR(3643)

Specificity

Predicted to cross-react with rat based on sequence homology (100%), but have not been tested.
Recognizes phospho-IR (β-subunit) (pTyr972).

Immunogen

A linear peptide corresponding to amino acid region encompassing the human, mouse and rat phospho-IR (pTyr972).

Application

Anti-phospho-IR (Tyr972) Antibody detects level of phospho-IR (Tyr972) & has been published & validated for use in WB.
Research Category
Signaling
Research Sub Category
Insulin/Energy Signaling

Target description

155 kDa

Physical form

100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg2+ and Ca2+), pH 7.3 containing 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide) and 50% glycerol.
Affinity purified

Storage and Stability

Stable for 2 years at -20°C from date of shipment.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Renan Fudoli Lins Vieira et al.
The Journal of physiology, 600(4), 797-813 (2021-01-16)
Time-restricted feeding (TRF, in which energy intake is restricted to 8 h/day during the dark phase) alone or combined with aerobic exercise (AE) training can prevent weight gain and metabolic disorders in Swiss mice fed a high-fat diet. The benefits of
Preparation, crystallization and preliminary X-ray analysis of threonine synthase from Streptococcus mutans.
De-Wei Tang,Lan-Fen Li,Ya-Mei Yu,Xiang-Yu Liu,Xiao-Dong Su,Xiaojun Zhao,Yu-He Liang
Protein and peptide letters null
Vitor R Muñoz et al.
Journal of cellular physiology, 233(6), 4791-4800 (2017-12-09)
The effects of physical exercise on insulin signaling and glycemic homeostasis are not yet fully understood. Recent findings elucidated the positive role of Rho-kinase (Rock) in increasing the glucose uptake through insulin receptor substrate-1 (IRS1) phosphorylation in the skeletal muscle.
Marina C Muñoz et al.
The Journal of endocrinology, 201(2), 185-197 (2009-03-03)
The I kappaB kinase-beta (IKK-beta)/nuclear factor-kappaB signaling pathway has been suggested to link inflammation with obesity and insulin resistance. In addition, angiotensin (Ang) II is able to induce insulin resistance and an inflammatory state through Ang II receptor type 1
Vitor Rosetto Muñoz et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 75(3), 432-436 (2019-01-01)
The insulin receptor substrate 1 regulates insulin-mediated glucose uptake and is a target of Rho-kinase (Rock); however, the relationship between age-related insulin resistance and Rock signaling specifically in skeletal muscle and adipose tissue is unknown. We evaluated the content and

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