T-041

Topiramate-D₁₂ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Fórmula empírica (notación de Hill): C₁₂D₁₂H₉NO₈S
• Número de CAS: 1279037-95-4
• Peso molecular: 351.44
• EC Number: 200-659-6
• MDL number: MFCD09752150
• UNSPSC Code: 41116107
• PubChem Substance ID: 329826605
• NACRES: NA.24

Propiedades

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 100 μg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• SMILES string: [2H]C([2H])([2H])C1(O[C@H]2CO[C@@]3(COS(N)(=O)=O)OC(O[C@H]3[C@H]2O1)(C([2H])([2H])[2H])C([2H])([2H])[2H])C([2H])([2H])[2H]
• InChI: 1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7?,8?,9-,12-/m0/s1/i1D3,2D3,3D3,4D3
• InChI key: KJADKKWYZYXHBB-FTZSVORRSA-N

Descripción

General description

Suitable uses for this certified solution standard include as an internal standard for quantitation of topiramate levels in biological matrices such as urine or isotope dilution methods by LC/MS or GC/MS for clinical toxicology, urine drug testing, or forensic analysis applications. Topiramate, sold under trade name Topamax^®, is an antiepileptic drug used for the treatment of seizures. Topiramate in combination with the stimulant phentermine constitute the active compounds in the new weight lose drug Qsymia^®.

Application

• Quantitative determination of topiramate in human plasma: A method employing liquid chromatography tandem mass spectrometry was developed to quantitatively determine topiramate in human plasma, highlighting the precision and applicability of using advanced analytical techniques for therapeutic drug monitoring in clinical settings (Popov et al., 2013).


• Dried blood spots technique for topiramate: The development and validation of a dried blood spots technique for quantitative determination of topiramate using liquid chromatography-tandem mass spectrometry was conducted. This method offers a minimally invasive sample collection option that could improve therapeutic drug monitoring for patients on topiramate (Popov et al., 2013).


• Therapeutic drug monitoring by LC-MS/MS: A study described a robust method for the therapeutic drug monitoring of topiramate using liquid chromatography-tandem mass spectrometry (LC-MS/MS), providing essential data on drug stability and concentration levels necessary for effective patient management (Matar, 2010).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Qsymia is a registered trademark of Vivus, Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Topamax is a registered trademark of Johnson & Johnson

Información de seguridad

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H370
• pcodes: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• target_organs: Eyes
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 49.5 °F - closed cup
• flash_point_c: 9.7 °C - closed cup