L-019

Lamotrigine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Fórmula empírica (notación de Hill): C₉H₇Cl₂N₅
• Número de CAS: 84057-84-1
• Peso molecular: 256.09
• UNSPSC Code: 41116107
• NACRES: NA.24

Propiedades

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 1.0 mg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• SMILES string: Nc1nnc(c(N)n1)-c2cccc(Cl)c2Cl
• InChI: 1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)
• InChI key: PYZRQGJRPPTADH-UHFFFAOYSA-N
• Gene Information: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Descripción

General description

Lamotrigine is an anticonvulsant approved for treatment of epilepsy and bipolar disorder. Sold under the trade name Lamictal^®, this phenyltriazine analog also is used off-label for treatment of clinical depression. This Snap-N-Spike^® Reference Solution is suitable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications such as forensic analysis and clinical toxicology.

Application

• Metabolic Impact in Bipolar Disorder: Lamotrigine is studied for its metabolic effects when used alongside antipsychotics in bipolar disorder management. The research, conducted through a network meta-analysis, provides insights into the mood stabilization and metabolic considerations during treatment (Kong et al., 2024).


• Forensic Application: Lamotrigine′s quantification in human plasma is critical in forensic science for ensuring accurate therapeutic monitoring and legal investigations. This application leverages HPLC-PDA techniques to analyze forensic samples, demonstrating the drug′s significance beyond clinical settings (Sánchez-Sellero et al., 2024).


• Advanced Drug Monitoring: A study has developed a method using LC-MS/MS for the simultaneous monitoring of lamotrigine among other antiepileptic drugs through dried blood and plasma spot sampling. This technique enhances the pharmacokinetic analysis and is pivotal for patient management in epilepsy treatment (Cao et al., 2024).


• Innovative Extraction Techniques: Research has introduced a molecularly imprinted polymer membrane for the selective extraction of lamotrigine, showcasing its utility in separating and quantifying this drug alongside other pharmaceuticals. This innovative approach benefits various biochemical assays and enhances drug analysis capabilities (Zhao et al., 2024).


• Enhanced Analytical Methodology: Lamotrigine′s determination in urine samples through a titania-based fabric phase sorptive extraction reflects its critical role in therapeutic drug monitoring. This method, paired with high-performance liquid chromatography, offers precise measurements essential for neurological disorder management (Ulusoy et al., 2024).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Lamictal is a registered trademark of GlaxoSmithKline LLC

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H370
• pcodes: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• target_organs: Eyes,Central nervous system
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 49.5 °F - closed cup
• flash_point_c: 9.7 °C - closed cup