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870602P

Avanti

PGPC

Avanti Research™ - A Croda Brand 870602P, powder

Sinónimos:

1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine

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1 MG
US$ 195,00
5 MG
US$ 629,00

US$ 195,00

Fecha estimada de envío08 de abril de 2025

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1 MG
US$ 195,00
5 MG
US$ 629,00

About This Item

Fórmula empírica (notación de Hill):
C29H56NO10P
Número de CAS:
89947-79-5
Peso molecular:
609.73
MDL number:
MFCD05863933
UNSPSC Code:
12352211
NACRES:
NA.25

US$ 195,00

Fecha estimada de envío08 de abril de 2025

Solicitar un pedido a granel

form

powder

packaging

pkg of 1 × 1 mg (870602P-1mg)
pkg of 1 × 5 mg (870602P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 870602P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCC(O)=O)=O)COC(CCCCCCCCCCCCCCC)=O)=O

InChI

1S/C29H56NO10P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-20-28(33)37-24-26(40-29(34)21-18-19-27(31)32)25-39-41(35,36)38-23-22-30(2,3)4/h26H,5-25H2,1-4H3,(H-,31,32,35,36)/t26-/m1/s1

InChI key

CDZVJFRXJAUXPP-AREMUKBSSA-N

Categorías relacionadas

General description

1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine (PGPC) is a constituent of oxidatively modified low density lipoproteins (oxLDLs).[1] It is synthesized from the non-enzymatic oxidation of a major low-density lipoproteins (LDL) phospholipid, 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (PAPC).[2]

Application

1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine (PGPC) has been used to study its effect on plasma membrane nanoplatforms using single-molecule microscopy.[3]

Biochem/physiol Actions

1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine (PGPC) acts as an inducer of inflammation, proliferation or apoptosis in cultured vascular smooth muscle cells[1] and macrophages.[2] It is accumulated in atherosclerotic lesions.[1]

Packaging

5 mL Clear Glass Sealed Ampule (870602P-1mg)
5 mL Clear Glass Sealed Ampule (870602P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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Certificados de análisis (COA)

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The oxidized phospholipids POVPC and PGPC inhibit growth and induce apoptosis in vascular smooth muscle cells
Fruhwirth GO, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1761(9), 1060-1069 (2006)
The role of high-density lipoproteins in oxidation and inflammation
Van Lenten B, et al.
Trends in Cardiovascular Medicine, 11(3-4), 155-161 (2001)
Oxidized phospholipids inhibit the formation of cholesterol-dependent plasma membrane nanoplatforms
Brameshuber M, et al.
Biophysical Journal, 110(1), 205-213 (2016)
Alexandra Moumtzi et al.
Journal of lipid research, 48(3), 565-582 (2006-12-01)
Lipid oxidation is now thought to be an initiating and sustaining event in atherogenesis. Oxidatively fragmented phospholipids, namely 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC) and 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC), present in minimally modified LDL and atherosclerotic lesions, have been reported to elicit a wide range of
Mario Brameshuber et al.
Biophysical journal, 110(1), 205-213 (2016-01-09)
We previously developed a single-molecule microscopy method termed TOCCSL (thinning out clusters while conserving stoichiometry of labeling), which allows for direct imaging of stable nanoscopic platforms with raft-like properties diffusing in the plasma membrane. As a consensus raft marker, we
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