700071P
Avanti
24(R)-hydroxycholesterol
Avanti Research™ - A Croda Brand
Sinónimos:
5-cholestene-3β,24-diol ; 24-hydroxycholest-5-en-3-ol
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About This Item
Fórmula empírica (notación de Hill):
C27H46O2
Número de CAS:
Peso molecular:
402.65
UNSPSC Code:
12352211
NACRES:
NA.25
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description
cholest-5-ene-3β,24(R)-diol
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700071P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
Categorías relacionadas
General description
24-hydroxycholesterol (24-OH) is an oxidized product of cholesterol. It is synthesized in the presence of enzyme 24S-hydroxylase (CYP46A1).
Biochem/physiol Actions
24(S)-hydroxycholesterol is preferred over 24(R)-hydroxycholesterol by human 7α-hydroxylase. However, the porcine enzyme is active towards both isomers. 24-hydroxycholesterol (24-OH) favors sirtuin 1 expression and reduces the tau protein phosphorylation.
Packaging
5 mL Amber Glass Screw Cap Vial (700071P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
No data available
flash_point_c
No data available
Certificados de análisis (COA)
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M Norlin et al.
Journal of lipid research, 41(10), 1629-1639 (2000-10-03)
(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this oxysterol. In the
Gabriella Testa et al.
Redox biology, 17, 423-431 (2018-06-09)
It is now established that cholesterol oxidation products (oxysterols) are involved in several events underlying Alzheimer's disease (AD) pathogenesis. Of note, certain oxysterols cause neuron dysfunction and degeneration but, recently, some of them have been shown also to have neuroprotective
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