934216
NanoFabTx™ - Mannose Lipid Mix
for synthesis of mannose-targeted liposomes
Sinónimos:
Liposome synthesis kit, Small molecule drug formulation kit
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About This Item
Código UNSPSC:
12352211
En este momento no podemos mostrarle ni los precios ni la disponibilidad
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Nivel de calidad
temp. de almacenamiento
−20°C
Categorías relacionadas
Aplicación
NanoFabTx™ Mannose Lipid Mix is a ready-to-use curated lipid mixture containing rationally selected lipids and step by step instructions for synthesizing mannose targeted liposomes.Mannose receptors are over expressed on several cancer cells. Mannose receptors are also over expressed by macrophages, which play a critical role in inflammatory responses. Thus the mannose receptor can be used to achieve targeted delivery of drugs to these cells. The liposomes containing the mannose ligand will be internalized by the cells that over express the mannose receptors. Such a delivery technique will help in achieving targeted delivery of the drugs and avoid off target effects, which is a major side effect of many cancer therapies.
The mannose targeted- liposomes synthesized from the NanoFabTx™ Mannose Lipid Mix enable users to 1) encapsulate a wide variety of small molecules and 2) selectively target cells which overexpress mannose receptors, such as macrophages and certain cancer cells, without the need for lengthy trial-and-error optimization.
The mannose targeted- liposomes synthesized from the NanoFabTx™ Mannose Lipid Mix enable users to 1) encapsulate a wide variety of small molecules and 2) selectively target cells which overexpress mannose receptors, such as macrophages and certain cancer cells, without the need for lengthy trial-and-error optimization.
Características y beneficios
- A ready-to-use lipid blend for the synthesis of Mannose targeted liposomes
- Step-by-step protocols (extrusion, microfluidics) developed and tested by our formulation scientists
- Flexible synthesis tool to create uniform and reproducible liposomes
- Mannose ligand enables targeted drug delivery
- A lipid film hydration and extrusion protocol
- A microfluidics protocol using commercial platforms or syringe pumps
For more information, please refer to the protocol under the Protocol section of this page.
Información legal
NanoFabTx is a trademark of Sigma-Aldrich Co. LLC
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
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Certificados de análisis (COA)
Lot/Batch Number
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Drug-free mannosylated liposomes inhibit tumor growth by promoting the polarization of tumor-associated macrophages
Ye J, et al.
International journal of nanomedicine, 14, 3203-3220 (2019)
Mannosylated liposomes improve therapeutic effects of paclitaxel in colon cancer models
Xiong M, et al.
Journal of Microencapsulation, 34, 513- 521 (2017)
Mannosylated liposomes for targeted gene delivery
Kong F, et al.
International journal of nanomedicine, 7, 1079-1089 (2012)
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
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