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909874

Sigma-Aldrich

N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(D,L lactide)

PEG average Mn 5,000, PDLA average Mn 16,000

Sinónimos:

NHS ester PEG-PDLA, NHS ester PEG-PLA, NHS-PEG-PDLA, NHS-PEG-PLA

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About This Item

Fórmula lineal:
HO(C3H4O2)m(C2H4O)nC7H8NO4
UNSPSC Code:
12352005
NACRES:
NA.23

form

powder or chunks

mol wt

PDLA average Mn 16,000 (by NMR)
PEG average Mn 5,000 (by NMR)

color

white to tan

storage temp.

−20°C

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Application

N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(D,L lactide) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLA block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). The NHS functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Numerous glutamine analogues have been reported as irreversible inhibitors of the glucosamine-6-phosphate (GlcN-6-P) synthase in pathogenic Candida albicans in the last 3.5 decades. Among the reported inhibitors, the most effective N3-(4-methoxyfumaroyl)-l-2,3-diaminopropanoic acid (FMDP) has been extensively studied in order to
Ren Zhong Xiao et al.
International journal of nanomedicine, 5, 1057-1065 (2010-12-21)
Due to their small particle size and large and modifiable surface, nanoparticles have unique advantages compared with other drug carriers. As a research focus in recent years, polyethylene glycol-polylactic acid (PEG-PLA) block copolymer and its end-group derivative nanoparticles can enhance
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these

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