IKZF1
IKAROS family zinc finger 1 (Ikaros)
Sinónimos:
Hs.54452, IK1, IKAROS, LYF1, PRO0758, ZNFN1A1, hIk-1
Especie:
Human IKZF1 (10320), Mouse Ikzf1 (22778), Rat Ikzf1 (305501), sheep IKZF1 (101107435), dog IKZF1 (483231), Domestic Rabbit IKZF1 (100356499), Horse IKZF1 (100052437), chicken IKZF1 (395974), domestic guinea pig Ikzf1 (100734033), domestic cat IKZF1 (101085701) ...Más
ID UniProtKB:
ID del gen:
- Human(10320) Summary: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2011]
- Mouse(22778) IKAROS family zinc finger 1
- Rat(305501) IKAROS family zinc finger 1
- sheep(101107435) IKAROS family zinc finger 1 (Ikaros)
- dog(483231) IKAROS family zinc finger 1 (Ikaros)
- Domestic Rabbit(100356499) IKAROS family zinc finger 1 (Ikaros)
- Horse(100052437) IKAROS family zinc finger 1 (Ikaros)
- chicken(395974) IKAROS family zinc finger 1 (Ikaros)
- domestic guinea pig(100734033) IKAROS family zinc finger 1 (Ikaros)
- domestic cat(101085701) IKAROS family zinc finger 1 (Ikaros)
- cow(541154) IKAROS family zinc finger 1 (Ikaros)
- naked mole-rat(101699759) IKAROS family zinc finger 1 (Ikaros)
- Zebrafish(30177) IKAROS family zinc finger 1 (Ikaros)
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Ikaros Antibody, clone Ik14, clone Ik14, from mouse,
Reactividad de especies
human
Aplicación
ChIP
western blot
western blot
Anti-Ikaros antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
western blot
Anti-Ikaros Antibody, clone 4E9, clone 4E9, from mouse,
Reactividad de especies
human, mouse
Aplicación
ChIP
flow cytometry
western blot
flow cytometry
western blot
Anti-IKAROS Antibody, from rabbit, purified by affinity chromatography,
Reactividad de especies
human, mouse, rat
Aplicación
immunocytochemistry
western blot
western blot
esiRNA
Referencia del producto
Descripción
Especie