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Merck

CYP17A1

cytochrome P450, family 17, subfamily A, polypeptide 1

Sinónimos:
CPT7, CYP17, P450C17, S17AH
Especie:
Human CYP17A1 (1586), Mouse Cyp17a1 (13074), Rat Cyp17a1 (25146), Horse CYP17A1 (100034232), Zebrafish cyp17a1 (399692), cow CYP17A1 (281739), sheep CYP17A1 (493968), domestic cat CYP17A1 (493967), chicken CYP17A1 (425056), dog CYP17A1 (477807)
ID UniProtKB:
P05093, Q5TZV7
ID del gen:
  • Human(1586) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]
  • Mouse(13074) cytochrome P450, family 17, subfamily a, polypeptide 1
  • Rat(25146) cytochrome P450, family 17, subfamily a, polypeptide 1
  • Horse(100034232) cytochrome P-450 17 alpha-hydroxylase/C17,20-lyase
  • Zebrafish(399692) cytochrome P450, family 17, subfamily A, polypeptide 1
  • cow(281739) cytochrome P450, family 17, subfamily A, polypeptide 1
  • sheep(493968) cytochrome P450, family 17, subfamily A, polypeptide 1
  • domestic cat(493967) cytochrome P450, family 17, subfamily A, polypeptide 1
  • chicken(425056) cytochrome P450, family 17, subfamily A, polypeptide 1
  • dog(477807) cytochrome P450, family 17, subfamily A, polypeptide 1

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
SAB5702868
Anti-CYP17A1 Antibody, clone 5D2H1, Rabbit Monoclonal, ,
Reactividad de especies
mouse
Aplicación
immunofluorescence
western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
SML1527
Acetato de abiraterona, ≥98% (HPLC),
Especie
human
1000818
Acetato de abiraterona, United States Pharmacopeia (USP) Reference Standard,
Especie
human
SML1375
Galeterone, ≥98% (HPLC),
Especie
human
C6019
Clotrimazole, ,
Especie
mouse, human
K1003
Ketoconazole, 99.0-101.0% (EP, titration),
Especie
mouse, human, rat

esiRNA

Referencia del producto
Descripción
Especie
EHU120611
MISSION® esiRNA, targeting human CYP17A1,
Especie
human
EHU100721
MISSION® esiRNA, targeting human CYP17A1-AS1,
Especie
human