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Merck

AGTR1

angiotensin II receptor, type 1

Sinónimos:
AG2S, AGTR1A, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, AT2R1A, AT2R1B, HAT1R
Especie:
Human AGTR1 (185), naked mole-rat Agtr1 (101714068), Domestic Rabbit AGTR1 (100009164), domestic guinea pig Agtr1 (100192325), sheep AGTR1 (443107), dog AGTR1 (403836), chicken AGTR1 (396065), cow AGTR1 (281607), domestic cat AGTR1 (101082936)
ID UniProtKB:
P30556, Q13725
ID del gen:
  • Human(185) Summary: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
  • naked mole-rat(101714068) angiotensin II receptor, type 1
  • Domestic Rabbit(100009164) angiotensin II receptor, type 1
  • domestic guinea pig(100192325) angiotensin II receptor, type 1
  • sheep(443107) angiotensin II receptor, type 1
  • dog(403836) angiotensin II receptor, type 1
  • chicken(396065) angiotensin II receptor, type 1
  • cow(281607) angiotensin II receptor, type 1
  • domestic cat(101082936) angiotensin II receptor, type 1

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Small Molecule - Agonist

Referencia del producto
Descripción
Especie
A8846
ProteoMass™ Angiotensin II MALDI-MS Standard, vial of 10 nmol,
Especie
human
A2900
[Val5]-Angiotensin II acetate salt hydrate, ≥95% (HPLC), powder,
Especie
mouse, human, rat
A6402
[Asn1, Val5]-Angiotensin II, ≥97% (HPLC),
Especie
mouse, human, rat

Small Molecule - Antagonist

Referencia del producto
Descripción
Especie
T8949
Telmisartan, ≥98% (HPLC), solid,
Especie
human
SML0142
Valsartan, ≥98% (HPLC),
Especie
human
1708762
Valsartan, United States Pharmacopeia (USP) Reference Standard,
Especie
human
1370462
Losartan Potassium, United States Pharmacopeia (USP) Reference Standard,
Especie
human
1643419
Telmisartan, United States Pharmacopeia (USP) Reference Standard,
Especie
human

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
AB15552
Anti-AT1 Receptor Antibody, Chemicon®, from rabbit,
Reactividad de especies
human, mouse, rat
Aplicación
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
ZRB2442
Anti-AGTR1 Antibody, clone 1I12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
bovine, canine, human, mouse, rat
Aplicación
affinity binding assay
immunocytochemistry
western blot
SAB5702971
Anti-AT1R/AGTR1 Antibody, clone 8W6G0, Rabbit Monoclonal, ,
Reactividad de especies
human
Aplicación
western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
C4042
Captopril, ≥98% (HPLC), powder,
Especie
human, rat
547905
2,2′:5′,2′′:5′′,2′′′-Quaterthiophene, 96%,
Especie
human, rat, mouse

Proteins

Referencia del producto
Descripción
Especie
HTS064M
ChemiSCREEN Human Angiotensin II Receptor, Type I Membrane Preparation, Human AT1 GPCR membrane preparation for Radioligand binding Assays & GTPγS binding.,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
EHU090121
MISSION® esiRNA, targeting human AGTR1,
Especie
human