V900351
5-Fluorocytosine
Vetec™, reagent grade, 99%
Synonym(s):
4-amino-5-fluoro-2(1H)-pyrimidinone, Flucytosine
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About This Item
Empirical Formula (Hill Notation):
C4H4FN3O
CAS Number:
Molecular Weight:
129.09
Beilstein:
127285
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
Pricing and availability is not currently available.
grade
reagent grade
product line
Vetec™
Assay
99%
mp
298-300 °C (dec.) (lit.)
storage temp.
2-8°C
SMILES string
NC1=NC(=O)NC=C1F
InChI
1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
InChI key
XRECTZIEBJDKEO-UHFFFAOYSA-N
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Biochem/physiol Actions
Nucleoside analog that has antifungal activities. 5-FC is deaminated by cytosine deaminase to product 5-fluorouracil, resulting in RNA miscoding. 5-Fluorocytosine inhibits DNA and RNA synthesis and interferes with ribosomal protein synthesis.
Legal Information
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
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Radha Rajasingham et al.
PLoS medicine, 9(9), e1001316-e1001316 (2012-10-12)
Cryptococcal meningitis (CM) is the most common form of meningitis in Africa. World Health Organization guidelines recommend 14-d amphotericin-based induction therapy; however, this is impractical for many resource-limited settings due to cost and intensive monitoring needs. A cost-effectiveness analysis was
Cestmir Altaner et al.
International journal of cancer, 134(6), 1458-1465 (2013-09-17)
Suicide gene therapy mediated by mesenchymal stem cells with their ability to engraft into tumors makes these therapeutic stem cells an attractive tool to activate prodrugs directly within the tumor mass. In this study, we evaluated the therapeutic efficacy of
A D Hartkopf et al.
Gynecologic oncology, 130(2), 362-368 (2013-05-17)
To preclinical assess the feasibility of combining oncolytic measles vaccine virus (MeV) with suicide gene therapy for ovarian cancer treatment. We genetically engineered a recombinant MeV armed with a yeast-derived bifunctional suicide gene that encodes for cytosine deaminase and uracil
Hong Jun Lee et al.
Cancer letters, 335(1), 58-65 (2013-02-09)
Prostate cancer is the most common malignancy among men. Prostate cancer-related deaths are largely attributable to the development of hormone resistance in the tumor. No effective chemotherapy has yet been developed for advanced prostate cancer. It is desirable if a
Xiaorong Sun et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 105(1), 57-63 (2012-09-04)
To investigate whether hypoxia targeted bifunctional suicide gene expression-cytosine deaminase (CD) and uracil phosphoribosyltransferase (UPRT) with 5-FC treatments can enhance radiotherapy. Stable transfectants of R3327-AT cells were established which express a triple-fusion-gene: CD, UPRT and monomoric DsRed (mDsRed) controlled by
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